Journal article
Glucagon-like peptide receptor agonists and risk for depression
Primary care diabetes, Vol.18(4), pp.422-426
08/2024
DOI: 10.1016/j.pcd.2024.05.005
PMID: 38852027
Abstract
Aims
Package labeling for weight loss formulations of semaglutide and liraglutide include a warning for suicidal thoughts and behaviors. The objective was to examine the association between glucagon-like peptide-1 receptor agonists (GLP-1RA) and incident depression.
Methods
This retrospective cohort study compared Veterans Health Administration patients initiated on a GLP-1RA versus a dipeptidyl peptidase-4 inhibitor (DPP-4i) between June 1, 2013 and June 30, 2020. The primary outcome was incident depression, defined as a new diagnosis of depression or new antidepressant prescription, within 1 year following drug initiation. Multivariable log-binomial regression was used to estimate relative risk, adjusted for confounding factors including patient demographics, comorbid conditions, and prior medication.
Results
Of 34,130 patients initiated on a GLP-1RA and 105,478 initiated on a DPP-4i, incident depression occurred in 7.7 % (n= 2263) and 6.3 % (n= 6602), respectively. After adjustment, the relative risk was 1.02 (95 % CI: 0.97 – 1.07), thus failing to demonstrate a significant increase in risk for incident depression following initiation of a GLP-1RA compared to DPP-4i. Relative risk estimates in all sensitivity analyses were also non-significant.
Conclusions
This study did not demonstrate a significant increase in risk for incident depression following GLP-1RA initiation.
Details
- Title: Subtitle
- Glucagon-like peptide receptor agonists and risk for depression
- Creators
- Gabriella A. Tagliapietra - Iowa City VA Health Care SystemMatthew A. Cantrell - Department of Pharmacy Services, Iowa City Veterans Affairs Health Care System, 601 Highway 6 West, Iowa City, IA 52246, USABrian C. Lund - Department of Pharmacy Services, Iowa City Veterans Affairs Health Care System, 601 Highway 6 West, Iowa City, IA 52246, USA
- Resource Type
- Journal article
- Publication Details
- Primary care diabetes, Vol.18(4), pp.422-426
- DOI
- 10.1016/j.pcd.2024.05.005
- PMID
- 38852027
- NLM abbreviation
- Prim Care Diabetes
- ISSN
- 1751-9918
- eISSN
- 1878-0210
- Publisher
- Elsevier Ltd
- Grant note
- Health Services Research and Development Service, Department of Veterans Affairs: CIN 13-412
This research was supported by the Iowa City VA Health Care System, Department of Pharmacy Services. Additional support was provided by the Health Services Research and Development Service, Department of Veterans Affairs (Dr. Lund, CIN 13-412) . None of these sponsors had any role in the study design, methods, analyses, and interpretation, or in preparation of the manuscript and the decision to submit it for publication. The views expressed in this article are those of the authors and do not necessarily reflect the position or policy of the Department of Veterans Affairs.
- Language
- English
- Electronic publication date
- 06/07/2024
- Date published
- 08/2024
- Academic Unit
- Epidemiology; Pharmacy Practice and Science
- Record Identifier
- 9984643653502771
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