Glucan-binding proteins of the oral streptococci

J A Banas; M M Vickerman

doi:10.1177/154411130301400203

Back

Glucan-binding proteins of the oral streptococci

Journal article

Open access

Peer reviewed

Glucan-binding proteins of the oral streptococci

J A Banas and M M Vickerman

Critical reviews in oral biology and medicine, Vol.14(2), pp.89-99

2003

DOI: 10.1177/154411130301400203

PMID: 12764072

Files and links (1)

url

https://doi.org/10.1177/154411130301400203View

Published (Version of record) Open Access

Abstract

The synthesis of extracellular glucan is an integral component of the sucrose-dependent colonization of tooth surfaces by species of the mutans streptococci. In investigators' attempts to understand the mechanisms of plaque biofilm development, several glucan-binding proteins (GBPs) have been discovered. Some of these, the glucosyltransferases, catalyze the synthesis of glucan, whereas others, designated only as glucan-binding proteins, have affinities for different forms of glucan and contribute to aspects of the biology of their host organisms. The functions of these latter glucan-binding proteins include dextran-dependent aggregation, dextranase inhibition, plaque cohesion, and perhaps cell wall synthesis. In some instances, their glucan-binding domains share common features, whereas in others the mechanism for glucan binding remains unknown. Recent studies indicate that at least some of the glucan-binding proteins modulate virulence and some can act as protective immunogens within animal models. Overall, the multiplicity of GBPs and their aforementioned properties are testimonies to their importance. Future studies will greatly advance the understanding of the distribution, function, and regulation of the GBPs and place into perspective the facets of their contributions to the biology of the oral streptococci.

Streptococcus mutans - metabolism

Streptococcus oralis - metabolism

Streptococcus sobrinus - metabolism

Virulence Factors

Bacterial Adhesion

Gene Expression Regulation, Enzymologic

Dental Plaque - microbiology

Glucosyltransferases - metabolism

Carrier Proteins - metabolism

Glucosyltransferases - chemistry

Streptococcus sanguis - metabolism

Lectins

Bacterial Proteins - metabolism

Glucans - metabolism

Glucosyltransferases - genetics

Details

Title: Subtitle: Glucan-binding proteins of the oral streptococci
Creators: J A Banas - Center for Immunology and Microbial Disease, Albany Medical College, NY 12208, USA. BanasJ@mail.amc.edu
M M Vickerman
Resource Type: Journal article
Publication Details: Critical reviews in oral biology and medicine, Vol.14(2), pp.89-99
DOI: 10.1177/154411130301400203
PMID: 12764072
NLM abbreviation: Crit Rev Oral Biol Med
ISSN: 1045-4411
eISSN: 1544-1113
Publisher: United States
Grant note: DE10058 / NIDCR NIH HHS DE11090 / NIDCR NIH HHS
Language: English
Date published: 2003
Academic Unit: Pediatric Dentistry; Dental Research
Record Identifier: 9984065808702771

Metrics

20 Record Views

265 Times Cited - Web of Science

See more details