GlucoWatch G2 Biographer alarm reliability during hypoglycemia in children

Eva Tsalikian; Craig Kollman; Nelly Mauras; Stuart Weinzimer; Bruce Buckingham; Dongyuan Xing; Roy Beck; Katrina Ruedy; William Tamborlane; Rosanna Fiallo-Scharer; Diabetes Research in Children Network (DirecNet) Study Group

doi:10.1089/dia.2004.6.559

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GlucoWatch G2 Biographer alarm reliability during hypoglycemia in children

Journal article

Peer reviewed

GlucoWatch G2 Biographer alarm reliability during hypoglycemia in children

Eva Tsalikian, Craig Kollman, Nelly Mauras, Stuart Weinzimer, Bruce Buckingham, Dongyuan Xing, Roy Beck, Katrina Ruedy, William Tamborlane, Rosanna Fiallo-Scharer, …

Diabetes technology & therapeutics, Vol.6(5), pp.559-566

10/2004

DOI: 10.1089/dia.2004.6.559

PMCID: PMC2302787

PMID: 15628809

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https://www.ncbi.nlm.nih.gov/pmc/articles/2302787View

Open Access

Abstract

The GlucoWatch G2 Biographer (GW2B) (Cygnus, Inc., Redwood City, CA) provides near-continuous monitoring of glucose values in near real time. This device is equipped with two types of alarms to detect hypoglycemia. The hypoglycemia alarm is triggered when the current glucose measurement falls below the level set by the user. The "down alert" alarm is triggered when extrapolation of the current glucose trend anticipates hypoglycemia to occur within the next 20 min. We used data from an inpatient accuracy study to assess the performance of these alarms. During a 24-h clinical research center stay, 89 children and adolescents with Type 1 diabetes mellitus (3.5-17.7 years old) wore 174 GW2B devices and had frequent serum glucose determinations during the day and night. Sensitivity to detect hypoglycemia (reference glucose < or = 60 mg/dL) during an insulin-induced hypoglycemia test was 24% with the hypoglycemia alarm alone and 88% when combined with the down alert alarm. Overnight sensitivity from 11 p.m. to 6 a.m. was 23% with the hypoglycemia alarm alone and 77% when combined with the down alert alarm. For 16% of hypoglycemia alarms, the reference glucose was above 70 mg/dL for 30 min before and after the time of the alarm. For the two alarm types combined, the corresponding false-positive rate increased to 62%. The down alert alarm substantially improves the sensitivity of the GW2B to detect hypoglycemia at the price of a large increase in the false alarm rate. The utility of these alarms in the day-to-day management of children with diabetes remains to be determined.

Hypoglycemia - diagnosis

Insulin - pharmacology

Reproducibility of Results

Monitoring, Ambulatory - methods

Humans

Child, Preschool

Diabetes Mellitus, Type 1 - drug therapy

Blood Glucose - drug effects

Hypoglycemia - prevention & control

Inpatients

Algorithms

Diabetes Mellitus, Type 1 - blood

Adolescent

Hypoglycemia - blood

Blood Glucose - metabolism

Child

Insulin - adverse effects

Insulin - therapeutic use

Equipment Failure

Details

Title: Subtitle: GlucoWatch G2 Biographer alarm reliability during hypoglycemia in children
Creators: Eva Tsalikian - DirecNet Coordinating Center, Jaeb Center for Health Research, Tampa, FL 33647, USA. direcnet@jaeb.org
Craig Kollman
Nelly Mauras
Stuart Weinzimer
Bruce Buckingham
Dongyuan Xing
Roy Beck
Katrina Ruedy
William Tamborlane
Rosanna Fiallo-Scharer
Diabetes Research in Children Network (DirecNet) Study Group
Resource Type: Journal article
Publication Details: Diabetes technology & therapeutics, Vol.6(5), pp.559-566
DOI: 10.1089/dia.2004.6.559
PMID: 15628809
PMCID: PMC2302787
NLM abbreviation: Diabetes Technol Ther
ISSN: 1520-9156
eISSN: 1557-8593
Grant note: U10 HD041890 / NICHD NIH HHS RR00059 / NCRR NIH HHS U10 HD041915-01 / NICHD NIH HHS RR00070-41 / NCRR NIH HHS U10 HD041906 / NICHD NIH HHS U10 HD041919-01 / NICHD NIH HHS M01 RR000069 / NCRR NIH HHS U10 HD041918-01 / NICHD NIH HHS M01 RR000070 / NCRR NIH HHS RR06022 / NCRR NIH HHS M01 RR006022 / NCRR NIH HHS HD041890 / NICHD NIH HHS U10 HD041918 / NICHD NIH HHS U10 HD041906-01 / NICHD NIH HHS U10 HD041919 / NICHD NIH HHS U10 HD041908-01 / NICHD NIH HHS U10 HD041915 / NICHD NIH HHS HD041919-0 / NICHD NIH HHS M01 RR00069 / NCRR NIH HHS U01 HD041890-01 / NICHD NIH HHS M01 RR000059 / NCRR NIH HHS U10 HD041908 / NICHD NIH HHS HD041915 / NICHD NIH HHS U01 HD041890 / NICHD NIH HHS
Language: English
Date published: 10/2004
Academic Unit: Stead Family Department of Pediatrics; Fraternal Order of Eagles Diabetes Research Center
Record Identifier: 9984093214402771

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