Glucometabolic Changes Are Associated with Structural Gray Matter Alterations in Prodromal Dementia

Mélissa Gentreau; Christelle Reynes; Robert Sabatier; Jerome Maller; Chantal Meslin; Jeremy Deverdun; Emmanuelle Le Bars; Michel Raymond; Claire Berticat; Sylvaine Artero

doi:10.3233/JAD-220490

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Glucometabolic Changes Are Associated with Structural Gray Matter Alterations in Prodromal Dementia

Journal article

Peer reviewed

Glucometabolic Changes Are Associated with Structural Gray Matter Alterations in Prodromal Dementia

Mélissa Gentreau, Christelle Reynes, Robert Sabatier, Jerome Maller, Chantal Meslin, Jeremy Deverdun, Emmanuelle Le Bars, Michel Raymond, Claire Berticat and Sylvaine Artero

Journal of Alzheimer's disease, Vol.89(4), pp.1293-1302

01/01/2022

DOI: 10.3233/JAD-220490

PMID: 36031896

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https://hal.science/hal-03766366View

Open Access

Abstract

Background: Glucometabolic changes, such as high glycemic load (GL) diet and insulin resistance (IR), are potential risk factor of Alzheimer's disease (AD). Yet, the effect of these factors on brain alterations that contribute to AD pathology has not been clearly demonstrated.Objective: We aimed to assess the relationship of GL and IR with gray matter volumes involved in prodromal dementia.Methods: GL and Triglyceride-Glucose (TyG) index, an IR surrogate marker, were calculated in 497 participants who underwent magnetic resonance imaging (MRI). The gray matter volumes most related to prodromal dementia/mild cognitive impairment (diagnosed in 18/158 participants during the 7-year follow-up) were identified using a data-driven machine learning algorithm.Results: Higher GL diet was associated with reduced amygdala volume. The TyG index was negatively associated with the hippocampus, amygdala, and putamen volumes.Conclusion: These results suggest that GL and IR are associated with lower gray matter volumes in brain regions involved in AD pathology.

Endocrinology and metabolism

Human health and pathology

Life Sciences

Neurons and Cognition

Details

Title: Subtitle: Glucometabolic Changes Are Associated with Structural Gray Matter Alterations in Prodromal Dementia
Creators: Mélissa Gentreau - Université de Montpellier
Christelle Reynes - Université de Montpellier
Robert Sabatier - Université de Montpellier
Jerome Maller - Monash University
Chantal Meslin - Australian National University
Jeremy Deverdun - Université de Montpellier
Emmanuelle Le Bars - Université de Montpellier
Michel Raymond - Institut des Sciences de l'Evolution de Montpellier
Claire Berticat - Institut des Sciences de l'Evolution de Montpellier
Sylvaine Artero - Université de Montpellier
Resource Type: Journal article
Publication Details: Journal of Alzheimer's disease, Vol.89(4), pp.1293-1302
DOI: 10.3233/JAD-220490
PMID: 36031896
NLM abbreviation: J Alzheimers Dis
ISSN: 1387-2877
eISSN: 1875-8908
Publisher: IOS Press
Number of pages: 10
Language: English
Date published: 01/01/2022
Academic Unit: Radiology
Record Identifier: 9984848507102771

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