Journal article
Glucose metabolism in human malignant gliomas measured quantitatively with PET, 1-[C-11]glucose and FDG : Analysis of the FDG lumped constant
The Journal of nuclear medicine (1978), Vol.39(3), pp.440-448
1998
PMID: 9529289
Abstract
Calculation of the glucose metabolic rate (MRGlc) in brain with PET and 2-[18F]fluoro-2-deoxy-D-glucose (FDG) requires knowing the rate of uptake of FDG relative to glucose from plasma into metabolite pools in the tissue. The proportionality factor for this is the FDG lumped constant (LC[FDG]), the ratio of the volumes of distribution of FDG and glucose multiplied by the hexokinase phosphorylation ratio for the two hexoses, Km(Glc) x Vm(FDG)/Km(FDG) x Vm(Glc) x MRGlc equals the FDG metabolic rate (MRFDG) divided by the LC(FDG), i.e., MRGlc = MRFDG/LC(FDG) and LC(FDG) = MRFDG/MRGlc. This investigation tested the hypothesis that LC(FDG) is significantly higher in gliomas than it is in brain uninvolved with tumor.
Methods: We imaged 40 patients with malignant gliomas with 1-[11C]glucose followed by FDG. The metabolic rates MRGlc and MRFDG were estimated for glioma and contralateral brain regions of interest by an optimization program based on three-compartment, four-rate constant models for the two hexoses.
Results: The LC(FDG), estimated as MRFDG/MRGlc, in gliomas was 1.40 +/- 0.46 (mean +/- s.d.; range = 0.72-3.10), whereas in non-tumor-bearing contralateral brain, it was 0.86 +/- 0.14 (range = 0.61-1.21) (p < 0.001, glioma versus contralateral brain).
Conclusion: These data strongly suggest that the glioma LC(FDG) exceeds that of contralateral brain, that quantitation of the glioma MRGlc with FDG requires knowing the LC(FDG) specific for the glioma and that the LC(FDG) of normal brain is higher than previously reported estimates of about 0.50. 2-Fluoro-2-deoxy-D-glucose/PET studies in which glioma glucose metabolism is calculated by the autoradiographic approach with normal brain rate constants and LC(FDG) will overestimate glioma MRGlc, to the extent that the glioma LC(FDG) exceeds the normal brain LC(FDG). "Hot spots" visualized in FDG/PET studies of gliomas represent regions where MRGlc, LC(FDG) or their product is higher in glioma than it is in uninvolved brain tissue.
Details
- Title: Subtitle
- Glucose metabolism in human malignant gliomas measured quantitatively with PET, 1-[C-11]glucose and FDG : Analysis of the FDG lumped constant
- Creators
- A. M SPENCE - Departments of Neurology, Radiology Statistics and Neurological Surgery, University of Washington School of Medicine, Seattle, Washington, United StatesM MUZI - Departments of Neurology, Radiology Statistics and Neurological Surgery, University of Washington School of Medicine, Seattle, Washington, United StatesG. A OJEMANN - Departments of Neurology, Radiology Statistics and Neurological Surgery, University of Washington School of Medicine, Seattle, Washington, United StatesM. M GRAHAM - Departments of Neurology, Radiology Statistics and Neurological Surgery, University of Washington School of Medicine, Seattle, Washington, United StatesF O'SULLIVAN - Departments of Neurology, Radiology Statistics and Neurological Surgery, University of Washington School of Medicine, Seattle, Washington, United StatesK. A KROHN - Departments of Neurology, Radiology Statistics and Neurological Surgery, University of Washington School of Medicine, Seattle, Washington, United StatesJ. M LINK - Departments of Neurology, Radiology Statistics and Neurological Surgery, University of Washington School of Medicine, Seattle, Washington, United StatesT. K LEWELLEN - Departments of Neurology, Radiology Statistics and Neurological Surgery, University of Washington School of Medicine, Seattle, Washington, United StatesB LEWELLEN - Departments of Neurology, Radiology Statistics and Neurological Surgery, University of Washington School of Medicine, Seattle, Washington, United StatesS. D FREEMAN - Departments of Neurology, Radiology Statistics and Neurological Surgery, University of Washington School of Medicine, Seattle, Washington, United StatesM. S BERGER - Departments of Neurology, Radiology Statistics and Neurological Surgery, University of Washington School of Medicine, Seattle, Washington, United States
- Resource Type
- Journal article
- Publication Details
- The Journal of nuclear medicine (1978), Vol.39(3), pp.440-448
- Publisher
- Society of Nuclear Medicine; Reston, VA
- PMID
- 9529289
- ISSN
- 0161-5505
- eISSN
- 1535-5667
- Language
- English
- Date published
- 1998
- Academic Unit
- Radiology; Radiation Oncology
- Record Identifier
- 9984047772702771
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