Glucose-powered pulsatile release

Yasuhiro Nishii; Swapnil Gandhi; Eric Nuxoll

doi:10.1016/j.cherd.2015.11.024

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Journal article

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Peer reviewed

Glucose-powered pulsatile release

Yasuhiro Nishii, Swapnil Gandhi and Eric Nuxoll

Chemical engineering research & design, Vol.106, pp.298-307

02/2016

DOI: 10.1016/j.cherd.2015.11.024

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https://doi.org/10.1016/j.cherd.2015.11.024View

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Abstract

•Individual drug doses sequestered in pH-sensitive polymer depots.•Drug depots stacked alternately with barriers for sequential drug release.•Barriers contain immobilized enzyme to convert glucose to acid, triggering release.•Barriers contain sacrificial acid scavenger to control release timing.•Glucose-powered pulsatile release demonstrated experimentally, computationally. Pulsatile release is required for many drugs from hormones to vaccines, but automating this release typically requires elaborate pumping systems with electronic controls and transcutaneous catheters. This paper describes a materials-based approach to this functionality, using a combination of composite polymer membranes to provide discrete pulses of drug at preprogrammed intervals using only a static concentration of glucose in water. Drug is encapsulated in acid-sensitive polymer membranes. Enzymes which convert glucose to acid are immobilized in other polymer membranes, along with sacrificial acid scavengers. These membranes are stacked alternately into a polymer laminate and sealed around the bottom and edges. Glucose diffuses steadily into the top membrane and is converted to acid. This acid is consumed by the scavenger until the scavenger is exhausted, at which point it triggers the acid-sensitive drug membrane below. That membrane swells and delaminates from the stack, releasing its payload, and the process repeats, potentially with different drugs in each layer and different preprogrammed delay times between each dose. This paper provides the first experimental demonstration of such a system, characterizes its components, models the system computationally, and provides basic design rubrics for further development.

Controlled release

Glucose oxidase

Hydrogel

Pulsatile drug delivery

Reactive membranes

Details

Title: Subtitle: Glucose-powered pulsatile release
Creators: Yasuhiro Nishii - University of Iowa
Swapnil Gandhi - University of Iowa
Eric Nuxoll - University of Iowa
Resource Type: Journal article
Publication Details: Chemical engineering research & design, Vol.106, pp.298-307
DOI: 10.1016/j.cherd.2015.11.024
ISSN: 0263-8762
eISSN: 1744-3563
Publisher: Elsevier B.V
Grant note: DOI: 10.13039/100000001, name: National Science Foundation, award: 1133297; DOI: 10.13039/100000968, name: American Heart Association, award: 11SDG7600044; name: Institute of National Colleges of Technology, award: 2014-146
Language: English
Date published: 02/2016
Academic Unit: Pharmaceutical Sciences and Experimental Therapeutics; Chemical and Biochemical Engineering
Record Identifier: 9984196964902771

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