Glucose uptake heterogeneity of the leg muscles is similar between patients with multiple sclerosis and healthy controls during walking

John H Kindred; Nathaniel B Ketelhut; Thorsten Rudroff

doi:10.1016/j.clinbiomech.2014.12.005

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Glucose uptake heterogeneity of the leg muscles is similar between patients with multiple sclerosis and healthy controls during walking

Journal article

Open access

Peer reviewed

Glucose uptake heterogeneity of the leg muscles is similar between patients with multiple sclerosis and healthy controls during walking

John H Kindred, Nathaniel B Ketelhut and Thorsten Rudroff

Clinical biomechanics (Bristol), Vol.30(2), pp.159-165

02/2015

DOI: 10.1016/j.clinbiomech.2014.12.005

PMCID: PMC4323621

PMID: 25541392

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Abstract

Difficulties in ambulation are one of the main problems reported by patients with multiple sclerosis. A previous study by our research group showed increased recruitment of muscle groups during walking, but the influence of skeletal muscle properties, such as muscle fiber activity, has not been fully elucidated. The purpose of this investigation was to use the novel method of calculating glucose uptake heterogeneity in the leg muscles of patients with multiple sclerosis and compare these results to healthy controls. Eight patients with multiple sclerosis (4 men) and 8 healthy controls (4 men) performed 15 min of treadmill walking at a comfortable self-selected speed following muscle strength tests. Participants were injected with ≈ 8 mCi of [(18)F]-fluorodeoxyglucose during walking after which positron emission tomography/computed tomography imaging was performed. No differences in muscle strength were detected between multiple sclerosis and control groups (P>0.27). Within the multiple sclerosis, group differences in muscle volume existed between the stronger and weaker legs in the vastus lateralis, semitendinosus, and semimembranosus (P<0.03). Glucose uptake heterogeneity between the groups was not different for any muscle group or individual muscle of the legs (P>0.16, P≥0.05). Patients with multiple sclerosis and healthy controls showed similar muscle fiber activity during walking. Interpretations of these results, with respect to our previous study, suggest that walking difficulties in patients with multiple sclerosis may be more associated with altered central nervous system motor patterns rather than alterations in skeletal muscle properties.

Leg - physiology

Humans

Middle Aged

Male

Muscle, Skeletal - metabolism

Tomography, X-Ray Computed

Positron-Emission Tomography

Walking - physiology

Exercise Test

Glucose - metabolism

Adult

Fluorodeoxyglucose F18

Multiple Sclerosis - metabolism

Muscle Strength - physiology

Details

Title: Subtitle: Glucose uptake heterogeneity of the leg muscles is similar between patients with multiple sclerosis and healthy controls during walking
Creators: John H Kindred - Department of Health and Exercise Science, Integrative Neurophysiology Lab, Colorado State University, Fort Collins, CO, USA. Electronic address: john.kindred@colostate.edu
Nathaniel B Ketelhut - Department of Health and Exercise Science, Integrative Neurophysiology Lab, Colorado State University, Fort Collins, CO, USA. Electronic address: nathan.ketelhut@colostate.edu
Thorsten Rudroff - Department of Health and Exercise Science, Integrative Neurophysiology Lab, Colorado State University, Fort Collins, CO, USA. Electronic address: thorsten.rudroff@colostate.edu
Resource Type: Journal article
Publication Details: Clinical biomechanics (Bristol), Vol.30(2), pp.159-165
DOI: 10.1016/j.clinbiomech.2014.12.005
PMID: 25541392
PMCID: PMC4323621
NLM abbreviation: Clin Biomech (Bristol)
ISSN: 0268-0033
eISSN: 1879-1271
Publisher: England
Grant note: UL1 TR000154 / NCATS NIH HHS UL1 TR001082 / NCATS NIH HHS
Language: English
Date published: 02/2015
Academic Unit: Neurology; Health, Sport, and Human Physiology
Record Identifier: 9984002464802771

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