Journal article
Glutamate receptor agonists cause efflux of endogenous neuroactive amino acids from cerebellar neurons in culture
European journal of pharmacology, Vol.177(3), pp.195-199
1990
DOI: 10.1016/0014-2999(90)90270-G
PMID: 2155809
Abstract
Cultured neurons from rat cerebellum were used to examine the effects of glutamate receptor agonists on the release of endogenous amino acids and adenosine. Kainic acid exposure resulted in the release of glutamate, taurine, GABA and alanine in a dose- and calcium-dependent manner. Stimulation with quisqualic acid resulted in the dose- and calcium-dependent release of GABA. N-Methyl aspartic acid did not elicit the release of any neuroactive amino acids. These findings suggest that N-methyl aspartate receptors are not coupled to transmitter release in these cultures, and that kainate and quisqualate receptors may have different neuronal distributions.
Details
- Title: Subtitle
- Glutamate receptor agonists cause efflux of endogenous neuroactive amino acids from cerebellar neurons in culture
- Creators
- Keith L Rogers - Department of Pharmacology, University of Iowa College of Medicine, Iowa City, IA 52242, U.S.ARobert A Philibert - Department of Pharmacology, University of Iowa College of Medicine, Iowa City, IA 52242, U.S.AGary R Dutton - Department of Pharmacology, University of Iowa College of Medicine, Iowa City, IA 52242, U.S.A
- Resource Type
- Journal article
- Publication Details
- European journal of pharmacology, Vol.177(3), pp.195-199
- DOI
- 10.1016/0014-2999(90)90270-G
- PMID
- 2155809
- NLM abbreviation
- Eur J Pharmacol
- ISSN
- 0014-2999
- eISSN
- 1879-0712
- Publisher
- Elsevier B.V
- Language
- English
- Date published
- 1990
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Psychiatry; Iowa Neuroscience Institute; Neuroscience and Pharmacology
- Record Identifier
- 9984003967702771
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