Glutamate transmission in addiction

Peter W Kalivas; Ryan T LaLumiere; Lori Knackstedt; Haowei Shen

doi:10.1016/j.neuropharm.2008.07.011

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Journal article

Peer reviewed

Glutamate transmission in addiction

Peter W Kalivas, Ryan T LaLumiere, Lori Knackstedt and Haowei Shen

Neuropharmacology, Vol.56(1), pp.169-173

2009

DOI: 10.1016/j.neuropharm.2008.07.011

PMCID: PMC3280337

PMID: 18675832

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https://www.ncbi.nlm.nih.gov/pmc/articles/3280337View

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Abstract

Cortico-striatal glutamate transmission has been implicated in both the initiation and expression of addiction related behaviors, such as locomotor sensitization and drug-seeking. While glutamate transmission onto dopamine cells in the ventral tegmental area undergoes transient plasticity important for establishing addiction-related behaviors, glutamatergic plasticity in the nucleus accumbens is critical for the expression of these behaviors. This information points to the value of exploring pharmacotherapeutic manipulation of glutamate plasticity in treating drug addiction.

Drug-seeking

Nucleus accumbens

Sensitization

Glutamate

Ventral tegmental area

Details

Title: Subtitle: Glutamate transmission in addiction
Creators: Peter W Kalivas
Ryan T LaLumiere
Lori Knackstedt
Haowei Shen
Resource Type: Journal article
Publication Details: Neuropharmacology, Vol.56(1), pp.169-173
DOI: 10.1016/j.neuropharm.2008.07.011
PMID: 18675832
PMCID: PMC3280337
NLM abbreviation: Neuropharmacology
ISSN: 0028-3908
eISSN: 1873-7064
Publisher: Elsevier Ltd
Language: English
Date published: 2009
Academic Unit: Psychological and Brain Sciences; Iowa Neuroscience Institute
Record Identifier: 9984070212902771

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