Journal article
Glutamine and whey protein improve intestinal permeability and morphology in patients with Crohn's disease: a randomized controlled trial
Digestive diseases and sciences, Vol.57(4), pp.1000-1012
04/2012
DOI: 10.1007/s10620-011-1947-9
PMID: 22038507
Abstract
Increased intestinal permeability (IP) has been implicated in the etiopathogenesis, disease activity and relapse of Crohn's disease (CD). Glutamine, the major fuel for the enterocytes, may improve IP.
We evaluated the effect of oral glutamine on IP and intestinal morphology in patients with CD.
In a randomized controlled trial, consecutive patients with CD in remission phase with an abnormal IP were randomized to a glutamine group (GG) or active control group (ACG) and were given oral glutamine or whey protein, respectively, as 0.5 g/kg ideal body weight/day for 2 months. IP was assessed by the lactulose mannitol excretion ratio (LMR) in urine, and morphometry was performed by computerized image analysis system.
Patients (age 34.5 ± 10.5 years; 20 males) were assigned to the GG (n = 15) or ACG (n = 15). Fourteen patients in each group completed the trial. The LMR [median (range)] in GG and ACG at 2 months was 0.029 (0.006-0.090) and 0.033 (0.009-0.077), respectively, with P = 0.6133. IP normalized in 8 (57.1%) patients in each group (P = 1.000). The villous crypt ratio (VCR) [mean (SD)] in GG and ACG at 2 months was 2.68 (1.02) and 2.49 (0.67), respectively, (P = 0.347). At the end of 2 months LMR improved significantly in GG from 0.071 (0.041-0.254) to 0.029 (0.006-0.090) (P = 0.0012) and in ACG from 0.067 (0.040-0.136) to 0.033 (0.009-0.077) (P = 0.0063). VCR improved in the GG from 2.33 (0.77) to 2.68 (1.02) (P = 0.001), and in ACG from 2.26 (0.57) to 2.49 (0.67) (P = 0.009).
Intestinal permeability and morphology improved significantly in both glutamine and ACG.
Details
- Title: Subtitle
- Glutamine and whey protein improve intestinal permeability and morphology in patients with Crohn's disease: a randomized controlled trial
- Creators
- Jaya Benjamin - Department of Gastroenterology and Human Nutrition, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India. jayabenjamin2@rediffmail.comGovind MakhariaVineet AhujaK D Anand RajanMani KalaivaniSiddhartha Datta GuptaYogendra Kumar Joshi
- Resource Type
- Journal article
- Publication Details
- Digestive diseases and sciences, Vol.57(4), pp.1000-1012
- Publisher
- United States
- DOI
- 10.1007/s10620-011-1947-9
- PMID
- 22038507
- ISSN
- 0163-2116
- eISSN
- 1573-2568
- Language
- English
- Date published
- 04/2012
- Academic Unit
- Pathology
- Record Identifier
- 9984047646702771
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