Glycemic Control and Urinary Tract Infections in Women with Type 1 Diabetes: Results from the DCCT/EDIC

Sara M Lenherr; J Quentin Clemens; Barbara H Braffett; Patricia A Cleary; Rodney L Dunn; James M Hotaling; Alan M Jacobson; Catherine Kim; William Herman; Jeanette S Brown; Hunter Wessells; Aruna V Sarma; Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Research Group

doi:10.1016/j.juro.2016.04.071

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Glycemic Control and Urinary Tract Infections in Women with Type 1 Diabetes: Results from the DCCT/EDIC

Journal article

Peer reviewed

Glycemic Control and Urinary Tract Infections in Women with Type 1 Diabetes: Results from the DCCT/EDIC

Sara M Lenherr, J Quentin Clemens, Barbara H Braffett, Patricia A Cleary, Rodney L Dunn, James M Hotaling, Alan M Jacobson, Catherine Kim, William Herman, Jeanette S Brown, …

The Journal of urology, Vol.196(4), pp.1129-1135

10/2016

DOI: 10.1016/j.juro.2016.04.071

PMCID: PMC5025347

PMID: 27131462

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https://www.ncbi.nlm.nih.gov/pmc/articles/5025347View

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Abstract

We examined the relationship between glycemic control and urinary tract infections in women with type 1 diabetes mellitus. Women enrolled in the Epidemiology of Diabetes Interventions and Complications study, the observational followup of the Diabetes Control and Complications Trial, were surveyed to assess the rate of physician diagnosed urinary tract infections in the preceding 12 months. The relationship between glycated hemoglobin levels and number of urinary tract infections in the previous 12 months was assessed using a multivariable Poisson regression model. A total of 572 women were evaluated at year 17. Mean age was 50.7 ± 7.2 years, mean body mass index was 28.6 ± 5.9 kg/m(2), mean type 1 diabetes duration was 29.8 ± 5.0 years and mean glycated hemoglobin was 8.0% ± 0.9%. Of these women 86 (15.0%) reported at least 1 physician diagnosed urinary tract infection during the last 12 months. Higher glycated hemoglobin levels were significantly associated with number of urinary tract infections such that for every unit increase (1%) in recent glycated hemoglobin level, there was a 21% (p=0.02) increase in urinary tract infection frequency in the previous 12 months after adjusting for race, hysterectomy status, urinary incontinence, sexual activity in the last 12 months, peripheral and autonomic neuropathy, and nephropathy. The frequency of urinary tract infections increases with poor glycemic control in women with type 1 diabetes. This relationship is independent of other well described predictors of urinary tract infections and suggests that factors directly related to glycemic control may influence the risk of lower urinary tract infections.

Adolescent

Adult

Blood Glucose - metabolism

Body Mass Index

Diabetes Mellitus, Type 1 - blood

Diabetes Mellitus, Type 1 - complications

Diabetes Mellitus, Type 1 - drug therapy

Female

Glycated Hemoglobin A - metabolism

Humans

Hypoglycemic Agents - therapeutic use

Risk Factors

Surveys and Questionnaires

Urinary Incontinence - etiology

Urinary Tract Infections - blood

Urinary Tract Infections - complications

Young Adult

Details

Title: Subtitle: Glycemic Control and Urinary Tract Infections in Women with Type 1 Diabetes: Results from the DCCT/EDIC
Creators: Sara M Lenherr - Department of Surgery, Division of Urology, University of Utah, Salt Lake City, Utah
J Quentin Clemens - Department of Urology, University of Michigan, Ann Arbor, Michigan
Barbara H Braffett - The Biostatistics Center, The George Washington University, Rockville, Maryland
Patricia A Cleary - The Biostatistics Center, The George Washington University, Rockville, Maryland
Rodney L Dunn - Department of Urology, University of Michigan, Ann Arbor, Michigan
James M Hotaling - Department of Surgery, Division of Urology, University of Utah, Salt Lake City, Utah
Alan M Jacobson - Winthrop University Hospital, Research Institute, Mineola, New York
Catherine Kim - Department of Medicine, University of Michigan, Ann Arbor, Michigan
William Herman - Department of Medicine, University of Michigan, Ann Arbor, Michigan
Jeanette S Brown - Departments of Obstetrics, Gynecology, & Reproductive Sciences, Urology, and Epidemiology, University of California San Francisco, San Francisco, California
Hunter Wessells - University of Washington School of Medicine and Harborview Medical Center, Department of Urology, Seattle, Washington
Aruna V Sarma - Department of Urology, University of Michigan, Ann Arbor, Michigan. Electronic address: asarma@umich.edu
Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Research Group
Contributors: Linda G Snetselaar (Contributor) - University of Iowa, Fraternal Order of Eagles Diabetes Research Center
Resource Type: Journal article
Publication Details: The Journal of urology, Vol.196(4), pp.1129-1135
DOI: 10.1016/j.juro.2016.04.071
PMID: 27131462
PMCID: PMC5025347
NLM abbreviation: J Urol
ISSN: 0022-5347
eISSN: 1527-3792
Grant note: U01 DK094176 / NIDDK NIH HHS T32 DK007782 / NIDDK NIH HHS U01 DK094157 / NIDDK NIH HHS P30 DK020541 / NIDDK NIH HHS R01 DK083927 / NIDDK NIH HHS P30 DK089503 / NIDDK NIH HHS
Language: English
Date published: 10/2016
Academic Unit: Epidemiology; Fraternal Order of Eagles Diabetes Research Center; Internal Medicine
Record Identifier: 9984215142302771

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