Journal article
Glycerate from intestinal fructose metabolism induces islet cell damage and glucose intolerance
Cell metabolism, Vol.34(7), pp.1042-1053.e6
07/05/2022
DOI: 10.1016/j.cmet.2022.05.007
PMID: 35688154
Abstract
Dietary fructose, especially in the context of a high-fat western diet, has been linked to type 2 diabetes. Although the effect of fructose on liver metabolism has been extensively studied, a significant portion of the fructose is first metabolized in the small intestine. Here, we report that dietary fat enhances intestinal fructose metabolism, which releases glycerate into the blood. Chronic high systemic glycerate levels induce glucose intolerance by slowly damaging pancreatic islet cells and reducing islet sizes. Our findings provide a link between dietary fructose and diabetes that is modulated by dietary fat.
[Display omitted]
•High-fat diet increases fructose metabolism in the small intestine•Intestinal fructose metabolism releases glycerate into circulation•Circulating glycerate induces pancreatic islet cell damage•Circulating glycerate induces glucose intolerance
Dietary fructose has been linked to metabolic syndromes such as diabetes. Wu et al. discovered that fructose metabolism in the small intestine releases glycerate into the blood circulation, which damages pancreatic islet cells and induces glucose intolerance. Dietary fat further elevates intestinal fructose metabolism and resulting circulating glycerate levels, supporting the long-term effect of western diet on exacerbating metabolic syndromes.
Details
- Title: Subtitle
- Glycerate from intestinal fructose metabolism induces islet cell damage and glucose intolerance
- Creators
- Yanru Wu - Wuhan UniversityChi Wut Wong - Duke UniversityEric N. Chiles - Rutgers, The State University of New JerseyAllyson L. Mellinger - North Carolina State UniversityHosung Bae - University of California, IrvineSunhee Jung - University of California, IrvineTed Peterson - Duke UniversityJamie Wang - Duke UniversityMarcos Negrete - Duke UniversityQiang Huang - Second Affiliated Hospital of Xi'an Jiaotong UniversityLihua Wang - Duke UniversityCholsoon Jang - University of California, IrvineDavid C. Muddiman - North Carolina State UniversityXiaoyang Su - Rutgers, The State University of New JerseyIan Williamson - Duke UniversityXiling Shen - Terasaki Foundation
- Resource Type
- Journal article
- Publication Details
- Cell metabolism, Vol.34(7), pp.1042-1053.e6
- DOI
- 10.1016/j.cmet.2022.05.007
- PMID
- 35688154
- NLM abbreviation
- Cell Metab
- ISSN
- 1550-4131
- eISSN
- 1932-7420
- Publisher
- Elsevier Inc
- Language
- English
- Date published
- 07/05/2022
- Academic Unit
- Internal Medicine
- Record Identifier
- 9985217032202771
Metrics
3 Record Views