Journal article
Glycerol Monolaurate Inhibits Candida and Gardnerella vaginalis In Vitro and In Vivo but Not Lactobacillus
Antimicrobial agents and chemotherapy, Vol.54(2), pp.597-601
02/2010
DOI: 10.1128/AAC.01151-09
PMCID: PMC2812150
PMID: 20008774
Abstract
We investigated the effects of glycerol monolaurate (GML) on
Lactobacillus
,
Candida
, and
Gardnerella vaginalis
human vaginal microflora. Our previous work demonstrated that 6 months of GML treatment vaginally does not alter lactobacillus counts in monkeys.
Candida
and
G. vaginalis
are commonly associated with vaginal infections in women, many becoming chronic or recurrent.
In vitro
growth inhibition studies determined the effects of GML (0 to 500 μg/ml) against multiple
Candida
species and
G. vaginalis
. A randomized, double-blind study investigated the effects of GML on vaginal microflora
Lactobacillus
,
Candida
, and
G. vaginalis
in colonized or infected women (
n
= 36). Women self-administered intravaginal gels containing 0% (
n
= 14), 0.5% (
n
= 13), or 5% (
n
= 9) GML every 12 h for 2 days. Vaginal swabs were collected before and immediately after the first gel administration and 12 h after the final gel administration. Swabs were tested for
Lactobacillus
,
Candida
,
G. vaginalis
, and GML.
In vitro
GML concentrations of 500 μg/ml were candicidal for all species tested, while a concentration of 10 μg/ml was bactericidal for
G. vaginalis
. Control and GML gels applied vaginally in women did not alter vaginal pH or
Lactobacillus
counts. Control gels reduced
G. vaginalis
counts but not
Candida
counts, whereas GML gels reduced both
Candida
and
G. vaginalis
. No adverse events were reported by participating women. GML is antimicrobial for
Candida
and
G. vaginalis in vitro
. Vaginal GML gels in women do not affect
Lactobacillus
negatively but significantly reduce
Candida
and
G. vaginalis
.
Details
- Title: Subtitle
- Glycerol Monolaurate Inhibits Candida and Gardnerella vaginalis In Vitro and In Vivo but Not Lactobacillus
- Creators
- Kristi L Strandberg - Johnson & Johnson Consumer and Personal Products Worldwide, Skillman, New Jersey 08558Marnie L Peterson - Johnson & Johnson Consumer and Personal Products Worldwide, Skillman, New Jersey 08558Ying-Chi Lin - Johnson & Johnson Consumer and Personal Products Worldwide, Skillman, New Jersey 08558Melinda C Pack - Johnson & Johnson Consumer and Personal Products Worldwide, Skillman, New Jersey 08558David J Chase - Johnson & Johnson Consumer and Personal Products Worldwide, Skillman, New Jersey 08558Patrick M Schlievert - Johnson & Johnson Consumer and Personal Products Worldwide, Skillman, New Jersey 08558
- Resource Type
- Journal article
- Publication Details
- Antimicrobial agents and chemotherapy, Vol.54(2), pp.597-601
- DOI
- 10.1128/AAC.01151-09
- PMID
- 20008774
- PMCID
- PMC2812150
- NLM abbreviation
- Antimicrob Agents Chemother
- ISSN
- 0066-4804
- eISSN
- 1098-6596
- Publisher
- American Society for Microbiology (ASM)
- Language
- English
- Date published
- 02/2010
- Academic Unit
- Microbiology and Immunology; Internal Medicine
- Record Identifier
- 9984001142202771
Metrics
37 Record Views