Journal article
Glycerol Monolaurate Microbicide Protection against Repeat High-Dose SIV Vaginal Challenge
PloS one, Vol.10(6), pp.e0129465-e0129465
2015
DOI: 10.1371/journal.pone.0129465
PMCID: PMC4461171
PMID: 26057743
Abstract
Measures to prevent sexual mucosal transmission are critically needed, particularly to prevent transmission to young women at high risk in the microepidemics in South Africa that disproportionally contribute to the continued pandemic. To that end, microbicides containing anti-retroviral (ARV) agents have been shown to prevent transmission, but with efficacy limited both by adherence and pre-existing innate immune and inflammatory conditions in the female reproductive tract (FRT). Glycerol monolaurate (GML) has been proposed as a microbicide component to enhance efficacy by blocking these transmission-facilitating innate immune response to vaginal exposure. We show here in an especially rigorous test of protection in the SIV-rhesus macaque model of HIV-1 transmission to women, that GML used daily and before vaginal challenge protects against repeat high doses of SIV by criteria that include virological and immunological assays to detect occult infection. We also provide evidence for indirect mechanisms of action in GML-mediated protection. Developing a sustained formulation for GML delivery could contribute an independent, complementary protective component to an ARV-containing microbicide.
Details
- Title: Subtitle
- Glycerol Monolaurate Microbicide Protection against Repeat High-Dose SIV Vaginal Challenge
- Creators
- Ashley T Haase - Department of Microbiology and Immunobiology, Medical School, University of Minnesota, Minneapolis, MN 55455, United States of AmericaEva Rakasz - Wisconsin National Primate Research Center, University of Wisconsin, Madison, WI 53715, United States of AmericaNancy Schultz-Darken - Wisconsin National Primate Research Center, University of Wisconsin, Madison, WI 53715, United States of AmericaKarla Nephew - Wisconsin National Primate Research Center, University of Wisconsin, Madison, WI 53715, United States of AmericaKimberly L Weisgrau - Wisconsin National Primate Research Center, University of Wisconsin, Madison, WI 53715, United States of AmericaCavan S Reilly - Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN 55455, United States of AmericaQingsheng Li - Department of Microbiology and Immunobiology, Medical School, University of Minnesota, Minneapolis, MN 55455, United States of AmericaPeter J Southern - Department of Microbiology and Immunobiology, Medical School, University of Minnesota, Minneapolis, MN 55455, United States of AmericaMeghan Rothenberger - Division of Infectious Diseases, Department of Medicine, Medical School, University of Minnesota, Minneapolis, MN 55455, United States of AmericaMarnie L Peterson - Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, United States of AmericaPatrick M Schlievert - Department of Microbiology and Immunobiology, Medical School, University of Minnesota, Minneapolis, MN 55455, United States of America
- Resource Type
- Journal article
- Publication Details
- PloS one, Vol.10(6), pp.e0129465-e0129465
- DOI
- 10.1371/journal.pone.0129465
- PMID
- 26057743
- PMCID
- PMC4461171
- NLM abbreviation
- PLoS One
- ISSN
- 1932-6203
- eISSN
- 1932-6203
- Publisher
- Public Library of Science; United States
- Grant note
- P51OD011106 / NIH HHS P51 OD011106 / NIH HHS RR020141-01 / NCRR NIH HHS RR15459-01 / NCRR NIH HHS AI071976 / NIAID NIH HHS
- Language
- English
- Date published
- 2015
- Academic Unit
- Microbiology and Immunology; Internal Medicine
- Record Identifier
- 9984002397602771
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