Glycerol monolaurate inhibition of human B cell activation

Micaela G Fosdick; Shannon Loftus; Isabella Phillips; Zeb R Zacharias; Jon C D Houtman

doi:10.1038/s41598-022-17432-4

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Glycerol monolaurate inhibition of human B cell activation

Journal article

Open access

Peer reviewed

Glycerol monolaurate inhibition of human B cell activation

Micaela G Fosdick, Shannon Loftus, Isabella Phillips, Zeb R Zacharias and Jon C D Houtman

Scientific reports, Vol.12(1), pp.13506-13506

08/05/2022

DOI: 10.1038/s41598-022-17432-4

PMCID: PMC9355977

PMID: 35931746

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https://doi.org/10.1038/s41598-022-17432-4View

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Abstract

Glycerol monolaurate (GML) is a naturally occurring antimicrobial agent used commercially in numerous products and food items. GML is also used as a homeopathic agent and is being clinically tested to treat several human diseases. In addition to its anti-microbial function, GML suppresses immune cell proliferation and inhibits primary human T cell activation. GML suppresses T cell activation by altering membrane dynamics and disrupting the formation of protein clusters necessary for intracellular signaling. The ability of GML to disrupt cellular membranes suggests it may alter other cell types. To explore this possibility, we tested how GML affects human B cells. We found that GML inhibits BCR-induced cytokine production, phosphorylation of signaling proteins, and protein clustering, while also changing cellular membrane dynamics and dysregulating cytoskeleton rearrangement. Although similar, there are also differences between how B cells and T cells respond to GML. These differences suggest that unique intrinsic features of a cell may result in differential responses to GML treatment. Overall, this study expands our understanding of how GML impacts the adaptive immune response and contributes to a broader knowledge of immune modulating monoglycerides.

Details

Title: Subtitle: Glycerol monolaurate inhibition of human B cell activation
Creators: Micaela G Fosdick - University of Iowa
Shannon Loftus
Isabella Phillips
Zeb R Zacharias
Jon C D Houtman
Resource Type: Journal article
Publication Details: Scientific reports, Vol.12(1), pp.13506-13506
DOI: 10.1038/s41598-022-17432-4
PMID: 35931746
PMCID: PMC9355977
NLM abbreviation: Sci Rep
eISSN: 2045-2322
Grant note: DOI: 10.13039/100000001, name: National Science Foundation, award: DBI-1559927, DBI-1559927; DOI: 10.13039/100000002, name: National Institutes of Health, award: P30CA086862, P30CA086862
Language: English
Date published: 08/05/2022
Academic Unit: Microbiology and Immunology; Pathology; Internal Medicine
Record Identifier: 9984297327302771

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