Journal article
Glycerol monolaurate inhibits the production of beta-lactamase, toxic shock syndrome toxin-1, and other staphylococcal exoproteins by interfering with signal transduction
Journal of bacteriology, Vol.176(14), pp.4204-4209
07/01/1994
DOI: 10.1128/jb.176.14.4204-4209.1994
PMID: 8021206
Abstract
Glycerol monolaurate (GML) is a naturally occurring surfactant that is used widely as an emulsifier in the food and cosmetics industries and is generally regarded as lacking in important biological activities. The recent observation that it inhibits the production of staphylococcal toxic shock toxin-1 (P. M. Schlievert, J. R. Deringer, M. H. Kim, S. J. Projan, and R. P. Novick, Antimicrob. Agents Chemother. 36:626-631, 1992) is therefore rather surprising and raises the interesting question of how such a compound might interact with cells. In this report, we show that GML inhibits the synthesis of most staphylococcal toxins and other exoproteins and that it does so at the level of transcription. We find that GML blocks the induction but not the constitutive synthesis of beta-lactamase, suggesting that it acts by interfering with signal transduction.
Details
- Title: Subtitle
- Glycerol monolaurate inhibits the production of beta-lactamase, toxic shock syndrome toxin-1, and other staphylococcal exoproteins by interfering with signal transduction
- Creators
- Steven J ProjanSusan Brown-SkrobotPatrick M SchlievertFrancois VandeneschRichard P Novick
- Resource Type
- Journal article
- Publication Details
- Journal of bacteriology, Vol.176(14), pp.4204-4209
- DOI
- 10.1128/jb.176.14.4204-4209.1994
- PMID
- 8021206
- NLM abbreviation
- J Bacteriol
- ISSN
- 0021-9193
- eISSN
- 1098-5530
- Publisher
- American Society for Microbiology
- Language
- English
- Date published
- 07/01/1994
- Description audience
- Academic
- Academic Unit
- Microbiology and Immunology; Internal Medicine
- Record Identifier
- 9984001121502771
Metrics
19 Record Views