Journal article
Glycogen accumulation in tibial nerves of experimentally diabetic and aging control rats
Journal of the neurological sciences, Vol.52(2), pp.289-303
1981
DOI: 10.1016/0022-510X(81)90012-5
PMID: 7310436
Abstract
Tibial nerves of streptozotocin-diabetic, alloxan-diabetic, and age-matched control rats were examined at 2 weeks and 2, 4, 8, and 12 months following the induction of diabetes. Glycogen-like granules accumulated within perineurial and Schwann cells of only the diabetic animals. This accumulation may reflect a metabolic abnormality in these cells which could account for the reduced conduction velocities seen in the peripheral nerves of these same diabetic rats (Moore et al. 1980a). Glycogen-like granules were also present and increased with age in myelinated axons of both diabetic and control rats. Quantitative data suggest that axonal accumulation of glycogen-like granules is related to aging or injury related phenomena to which diabetic axons may be more susceptible.
Details
- Title: Subtitle
- Glycogen accumulation in tibial nerves of experimentally diabetic and aging control rats
- Creators
- Steven A MooreRichard G PetersonDavid L FeltenBrian L O'Connor
- Resource Type
- Journal article
- Publication Details
- Journal of the neurological sciences, Vol.52(2), pp.289-303
- Publisher
- Elsevier B.V
- DOI
- 10.1016/0022-510X(81)90012-5
- PMID
- 7310436
- ISSN
- 0022-510X
- eISSN
- 1878-5883
- Language
- English
- Date published
- 1981
- Academic Unit
- Pathology
- Record Identifier
- 9984047761302771
Metrics
18 Record Views