Journal article
Glycosylated haemoglobin in children with insulin-dependent diabetes mellitus
Diabetologia, Vol.19(5), pp.423-426
11/1980
DOI: 10.1007/BF00281820
PMID: 7004960
Abstract
Glycosylated haemoglobin (HbA1) was measured serially by microcolumn chromatography in 38 children with newly diagnosed insulin-dependent diabetes. Initial HbA1 levels of 13.6 +/- 0.5% fell signficiantly from day 0 (prior to therapy) both to day 1 (1.6 +/- 0.2% decrease) and to day 3-5 (2.6 +/- 0.4% decrease) (P < 0.001). This drop correlated closely with changes in blood glucose (P < 0.001), less closely and inversely with plasma bicarbonate levels (P < 0.01), but not with prior duration of symptoms or changes in serum cholesterol and triglyceride concentrations. HbA1 levels reached a nadir of 8.2 +/- 0.3% 3 weeks to 6 months after diagnosis, and correlated with decreasing insulin dosage (P < 0.001). HbA1 levels rose again to 11.4 +/- 0.5% in 21 patients followed for more than 3-6 months. Our results indicate that (1) HbA1 level change rapidly during initial stabilization of insulin-dependent diabetes suggesting that glycosylation may not be entirely irreversible, and (2) HbA1 levels are consistent with clinical assessment of control during remission and postremission phases.
Details
- Title: Subtitle
- Glycosylated haemoglobin in children with insulin-dependent diabetes mellitus
- Creators
- D DanemanEva TsalikianFay HengstenbergDorothy J BeckerA. L Drash
- Resource Type
- Journal article
- Publication Details
- Diabetologia, Vol.19(5), pp.423-426
- DOI
- 10.1007/BF00281820
- PMID
- 7004960
- NLM abbreviation
- Diabetologia
- ISSN
- 0012-186X
- eISSN
- 1432-0428
- Language
- English
- Date published
- 11/1980
- Academic Unit
- Stead Family Department of Pediatrics; Fraternal Order of Eagles Diabetes Research Center
- Record Identifier
- 9984093600902771
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