Journal article
Glycosylation of Tetrabromobisphenol A in Pumpkin
Environmental science & technology, Vol.53(15), pp.8805-8812
08/06/2019
DOI: 10.1021/acs.est.9b02122
PMCID: PMC6931399
PMID: 31283198
Abstract
Tetrabromobisphenol A (TBBPA) is the most widely used brominated flame retardant (BFR), and it bioaccumulates throughout the food chains. Its fate in the first trophic level, plants, is of special interest. In this study, a four-day hydroponic exposure of TBBPA at a concentration of 1 μmol L–1 to pumpkin seedlings was conducted. A nontarget screening method for hydrophilic bromine-containing metabolites was modified, based on both typical isotope patterns of bromine and mass defect, and used to process mass spectra data. A total of 20 glycosylation and malonyl glycosylation metabolites were found for TBBPA in the pumpkin plants. Representative glycosyl TBBPA reference standards were synthesized to evaluate the contribution of this glycosylation process. Approximately 86% of parent TBBPA was metabolized to form those 20 glycosyl TBBPAs, showing that glycosylation was the most dominant metabolism pathway for TBBPA in pumpkin at the tested exposure concentration.
Details
- Title: Subtitle
- Glycosylation of Tetrabromobisphenol A in Pumpkin
- Creators
- Xingwang Hou - University of Chinese Academy of SciencesMiao Yu - Icahn School of Medicine at Mount SinaiAifeng Liu - CAS Key Laboratory of Biobased Materials, Qingdao Institute of Bioenergy and Bioprocess TechnologyXiaoyun Wang - University of Chinese Academy of SciencesYanlin Li - Department of Civil and Environmental EngineeringJiyan Liu - University of Chinese Academy of SciencesJerald L Schnoor - Department of Civil and Environmental EngineeringGuibin Jiang - University of Chinese Academy of Sciences
- Resource Type
- Journal article
- Publication Details
- Environmental science & technology, Vol.53(15), pp.8805-8812
- DOI
- 10.1021/acs.est.9b02122
- PMID
- 31283198
- PMCID
- PMC6931399
- NLM abbreviation
- Environ Sci Technol
- ISSN
- 0013-936X
- eISSN
- 1520-5851
- Publisher
- American Chemical Society
- Grant note
- DOI: 10.13039/100000066, name: National Institute of Environmental Health Sciences, award: P42ES013661-12; DOI: 10.13039/501100002855, name: Ministry of Science and Technology of the People's Republic of China, award: 2018YFC1800702; DOI: 10.13039/501100001809, name: National Natural Science Foundation of China, award: 21677158, 21621064; DOI: 10.13039/501100002367, name: Chinese Academy of Sciences, award: XDB14010400; name: Iowa Superfund Research Program; name: 1000-Talents Program of the Chinese Academy of Sciences
- Language
- English
- Date published
- 08/06/2019
- Academic Unit
- Civil and Environmental Engineering; Occupational and Environmental Health; IIHR--Hydroscience and Engineering; Iowa Superfund Research Program
- Record Identifier
- 9983997977702771
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