Glycosyltransferases and their products: cryptococcal variations on fungal themes

James Stacey Klutts; Aki Yoneda; Morgann C Reilly; Indrani Bose; Tamara L Doering

doi:10.1111/j.1567-1364.2006.00054.x

Back

Glycosyltransferases and their products: cryptococcal variations on fungal themes

Journal article

Open access

Peer reviewed

Glycosyltransferases and their products: cryptococcal variations on fungal themes

James Stacey Klutts, Aki Yoneda, Morgann C Reilly, Indrani Bose and Tamara L Doering

FEMS yeast research, Vol.6(4), pp.499-512

06/01/2006

DOI: 10.1111/j.1567-1364.2006.00054.x

PMID: 16696646

Files and links (1)

url

https://doi.org/10.1111/j.1567-1364.2006.00054.xView

Published (Version of record) Open Access

Abstract

Abstract Glycosyltransferases are specific enzymes that catalyse the transfer of monosaccharide moieties to biological substrates, including proteins, lipids and carbohydrates. These enzymes are present from prokaryotes to humans, and their glycoconjugate products are often vital for survival of the organism. Many glycosyltransferases found in fungal pathogens such as Cryptococcus neoformans do not exist in mammalian systems, making them attractive potential targets for selectively toxic agents. In this article, we present the features of this diverse class of enzymes, and review the fungal glycosyltransferases that are involved in synthesis of the cell wall, the cryptococcal capsule, glycoproteins and glycolipids. We specifically focus on enzymes that have been identified or studied in C. neoformans, and we consider future directions for research on glycosyltransferases in the context of this opportunistic pathogen.

glycan

glycosylation

polysaccharide

fungi

glycosyltransferase

Details

Title: Subtitle: Glycosyltransferases and their products: cryptococcal variations on fungal themes
Creators: James Stacey Klutts - Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO, USA
Aki Yoneda - Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO, USA
Morgann C Reilly - Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO, USA
Indrani Bose - Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO, USA
Tamara L Doering - Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO, USA
Resource Type: Journal article
Publication Details: FEMS yeast research, Vol.6(4), pp.499-512
DOI: 10.1111/j.1567-1364.2006.00054.x
PMID: 16696646
NLM abbreviation: FEMS Yeast Res
ISSN: 1567-1356
eISSN: 1567-1364
Publisher: Blackwell Publishing Ltd; Oxford, UK
Language: English
Date published: 06/01/2006
Academic Unit: Pathology
Record Identifier: 9984046820602771

Metrics

21 Record Views

46 Times Cited - Web of Science