Journal article
GnRH agonist and GnRH antagonist protocols: comparison of outcomes among good-prognosis patients using national surveillance data
Reproductive biomedicine online, Vol.29(3), pp.299-304
09/01/2014
DOI: 10.1016/j.rbmo.2014.05.007
PMID: 25043892
Abstract
Implantation and live birth rates resulting from IVF cycles using gonadotropin-releasing hormone (GnRH) agonist and (GnRH) antagonist IVF protocols were compared among good-prognosis patients using the Centers for Disease Control and Prevention's National Assisted Reproductive Technology Surveillance System 2009–2010 data (n = 203,302 fresh, autologous cycles). Bivariable and multivariable analyses were conducted between cycles to compare outcomes. Cycles were restricted as follows: age younger than 35 years, maximum FSH less than 10 mIU/mL, first assisted reproduction technology cycle and FSH dose less than 3601 IU. A subgroup analysis including only elective single embryo transfer was also carried out. Among good-prognosis patients, the GnRH-agonist protocol was associated with a lower risk of cancellation before retrieval (4.3 versus 5.2%; P < 0.05) or transfer (5.5 versus 6.8%; P < 0.05), and a higher live birth rate per transfer (adjusted odds ratio [OR] 1.13, confidence interval [CI] 1.03 to 1.25) than the GnRH-antagonist group. Among the elective single embryo transfer group, the GnRH-agonist protocol was associated with a higher implantation rate (adjusted odds ratio [OR] 1.36, CI 1.08 to 1.73) and a higher live birth rate (adjusted OR 1.33, CI 1.07 to 1.66) compared with the GnRH-antagonist protocol. The GnRH-antagonist group had lower rates of ovarian hyperstimulation syndrome. Among good-prognosis patients, agonist protocols decreased cancellation risk and increased odds of implantation and live birth. Antagonist protocols may confer decreased risk of hyperstimulation.
Details
- Title: Subtitle
- GnRH agonist and GnRH antagonist protocols: comparison of outcomes among good-prognosis patients using national surveillance data
- Creators
- Daniel Grow - Baystate Medical CenterJennifer F Kawwass - National Center for Chronic Disease Prevention and Health PromotionAniket D Kulkarni - Centers for Disease Control and PreventionTonji Durant - National Center for Chronic Disease Prevention and Health PromotionDenise J Jamieson - Emory UniversityMaurizio Macaluso - National Center for Chronic Disease Prevention and Health Promotion
- Resource Type
- Journal article
- Publication Details
- Reproductive biomedicine online, Vol.29(3), pp.299-304
- Publisher
- Elsevier Ltd
- DOI
- 10.1016/j.rbmo.2014.05.007
- PMID
- 25043892
- ISSN
- 1472-6483
- eISSN
- 1472-6491
- Language
- English
- Date published
- 09/01/2014
- Academic Unit
- Obstetrics and Gynecology; VPMA - Administration
- Record Identifier
- 9984446397802771
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