Journal article
Gonadal dysfunction and pelvic sonographic findings in females with thalassaemia major
Gynecological endocrinology, Vol.26(4), pp.307-310
04/01/2010
DOI: 10.3109/09513590903511471
PMID: 20021296
Abstract
Material and Methods. Twenty-five female patients followed for thalassaemia major constituted the study population. Sexual maturation and hormonal status were assessed. Pubertal and menstrual problems were investigated.
Results. There was one patient with delayed puberty and five patients with arrested puberty. Mean ferritin level in this group of patients was slightly but not significantly higher than patients with normal pubertal maturation (2620 +/- 994 ng/ml vs. 2409 +/- 1348 ng/ml, p > 0.05). There were 10 patients with primary amenorrhoea, three with secondary amenorrhoea, five with oligomenorrhoea and irregular menstruation and one with regular menstruation. Compared to menstruating patients, the mean uterine size was smaller (4.1 +/- 3.5 cm<SU3</SU vs. 52.8 +/- 14.5 cm<SU3</SU) in all patients with delayed and arrested puberty (p < 0.05). Ten patients were taking hormone replacement therapy (HRT). The mean uterine size in these patients was larger than that in patients with amenorrhoea who were not taking HRT, but smaller than that in menstruating patients (9.1 +/- 15.9 cm<SU3</SU, 2.7 +/- 1.3 cm<SU3</SU and 52.8 +/- 14.5 cm<SU3</SU, respectively) (p < 0.05).
Conclusion. Thalassaemia major has important side effects on the hypothaloma-pituitary-gonadal axis resulting in pubertal and menstrual abnormalities. HRT should be given to provide normal sexual maturation in these patients.
Details
- Title: Subtitle
- Gonadal dysfunction and pelvic sonographic findings in females with thalassaemia major
- Creators
- Aysun Karabulut - Denizli Devlet HastanesiYasemin Balci - Denizli State Hosp, Dept Paediat Hematol, Denizli, TurkeySemra Demirlenk - Denizli Devlet HastanesiSerap Semiz - Pamukkale University
- Resource Type
- Journal article
- Publication Details
- Gynecological endocrinology, Vol.26(4), pp.307-310
- DOI
- 10.3109/09513590903511471
- PMID
- 20021296
- NLM abbreviation
- Gynecol Endocrinol
- ISSN
- 0951-3590
- eISSN
- 1473-0766
- Publisher
- Taylor & Francis
- Number of pages
- 4
- Language
- English
- Date published
- 04/01/2010
- Academic Unit
- Obstetrics and Gynecology
- Record Identifier
- 9985123696502771
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