Journal article
Gout after Living Kidney Donation: Correlations with Demographic Traits and Renal Complications
American journal of nephrology, Vol.41(3), pp.231-240
01/01/2015
DOI: 10.1159/000381291
PMCID: PMC4522163
PMID: 25896309
Abstract
Background: The demographic and clinical correlates of gout after living kidney donation are not well described. Methods: Using a unique database that integrates national registry identifiers of U.S. living kidney donors (1987-2007) with billing claims from a private health insurer (2000-2007), we identified post-donation gout based on medical diagnosis codes or pharmacy fills for gout therapies. The frequencies and demographic correlates of gout after donation were estimated by Cox regression with left- and right-censoring. We also compared the rates of renal diagnoses among donors with and without gout, matched in the ratio 1:3 by age, sex, and race. Results: The study sample of 4,650 donors included 13.1% African Americans. By seven years, African Americans were almost twice as likely to develop gout as Caucasian donors (4.4 vs. 2.4%; adjusted hazard ratio, aHR, 1.8; 95% confidence interval (CI) 1.0-3.2). Post-donation gout risk also increased with older age at donation (aHR per year 1.05) and was higher in men (aHR 2.80). Gout rates were similar in donors and age- and sex-matched general non-donors (rate ratio 0.86; 95% CI 0.66-1.13). Compared to matched donors without gout, donors with gout had more frequent renal diagnoses, reaching significance for acute kidney failure (rate ratio 12.5; 95% CI 1.5-107.0), chronic kidney disease (rate ratio 5.0; 95% CI 2.1-11.7), and other disorders of the kidney (rate ratio 2.2; 95% CI 1.2-4.2). Conclusion: Donor subgroups at increased risk of gout include African Americans, older donors, and men. Donors with gout have a higher burden of renal complications after demographic adjustment. (C) 2015 S. Karger AG, Basel
Details
- Title: Subtitle
- Gout after Living Kidney Donation: Correlations with Demographic Traits and Renal Complications
- Creators
- Ngan N. Lam - Western UniversityAmit X. Garg - Western UniversityDorry L. Segev - Johns Hopkins UniversityMark A. Schnitzler - Saint Louis UniversityHuiling Xiao - Saint Louis UniversityDavid Axelrod - Dartmouth CollegeDaniel C. Brennan - Washington University in St. LouisBertram L. Kasiske - University of MinnesotaJanet E. Tuttle-Newhall - Saint Louis UniversityKrista L. Lentine - Saint Louis University
- Resource Type
- Journal article
- Publication Details
- American journal of nephrology, Vol.41(3), pp.231-240
- Publisher
- Karger
- DOI
- 10.1159/000381291
- PMID
- 25896309
- PMCID
- PMC4522163
- ISSN
- 0250-8095
- eISSN
- 1421-9670
- Number of pages
- 10
- Grant note
- Astellas; Astellas Pharmaceuticals KRESCENT postdoctoral fellowship award; Canadian Institutes of Health Research (CIHR) Clinical Investigator Program at Western University R01-DK096008; K24-DK101828 / National Institutes of Health (NIH)/National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) Canadian Institutes of Health Research Clinician-Scientist Award; Canadian Institutes of Health Research (CIHR) Roche; Roche Holding K24DK101828 / NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK)
- Language
- English
- Date published
- 01/01/2015
- Academic Unit
- Surgery
- Record Identifier
- 9984322828502771
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