Graft survival versus glaucoma treatment after penetrating or Descemet stripping automated endothelial keratoplasty

Matthew S Ward; Kenneth M Goins; Mark A Greiner; Anna S Kitzmann; John E Sutphin; Wallace L M Alward; Emily C Greenlee; Young H Kwon; M Bridget Zimmerman; Michael D Wagoner

doi:10.1097/ICO.0000000000000170

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Graft survival versus glaucoma treatment after penetrating or Descemet stripping automated endothelial keratoplasty

Journal article

Peer reviewed

Graft survival versus glaucoma treatment after penetrating or Descemet stripping automated endothelial keratoplasty

Matthew S Ward, Kenneth M Goins, Mark A Greiner, Anna S Kitzmann, John E Sutphin, Wallace L M Alward, Emily C Greenlee, Young H Kwon, M Bridget Zimmerman and Michael D Wagoner

Cornea, Vol.33(8), pp.785-789

08/2014

DOI: 10.1097/ICO.0000000000000170

PMID: 24915017

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Abstract

The aim of this study was to assess and compare the association of glaucoma therapy with graft survival after performing penetrating keratoplasty (PKP) and Descemet stripping automated endothelial keratoplasty (DSAEK). A retrospective chart review was performed of cases: primary PKP from January 1, 2003, to December 31, 2005, or primary DSAEK from January 1, 2006, to December 31, 2008. Eyes with a surgical indication of pseudophakic corneal edema were included in the statistical analysis. Eyes were stratified by glaucoma treatment into those with (1) no glaucoma treatment, (2) medical therapy only, or (3) surgical intervention. The main outcome measure was graft survival. Fifty-seven PKP-operated and 156 DSAEK-operated eyes met the inclusion criteria. After PKP and DSAEK, respectively, the 5-year Kaplan-Meier graft survival was 94.7% and 93.8% in eyes with no glaucoma treatment (P > 0.99), 93.8% and 96.3% in eyes with medical therapy only (P > 0.99), and 56.8% and 50% in eyes with surgical intervention (P > 0.99). After both procedures were performed, graft survival was significantly worse in eyes with surgical intervention compared with that in eyes with no glaucoma treatment (P < 0.0001) or in eyes with medical therapy alone (P < 0.0001). PKP and DSAEK have comparable graft survival in eyes without glaucoma management and in those with comparable glaucoma management.

Descemet Stripping Endothelial Keratoplasty

Intraocular Pressure

Humans

Middle Aged

Glaucoma - drug therapy

Glaucoma Drainage Implants

Male

Glaucoma - surgery

Antihypertensive Agents - therapeutic use

Filtering Surgery

Corneal Edema - surgery

Pseudophakia - physiopathology

Pseudophakia - surgery

Keratoplasty, Penetrating

Aged, 80 and over

Graft Survival - physiology

Adult

Female

Glaucoma - therapy

Aged

Retrospective Studies

Corneal Edema - physiopathology

Details

Title: Subtitle: Graft survival versus glaucoma treatment after penetrating or Descemet stripping automated endothelial keratoplasty
Creators: Matthew S Ward - University of Iowa
Kenneth M Goins
Mark A Greiner
Anna S Kitzmann
John E Sutphin
Wallace L M Alward
Emily C Greenlee
Young H Kwon
M Bridget Zimmerman
Michael D Wagoner
Resource Type: Journal article
Publication Details: Cornea, Vol.33(8), pp.785-789
Publisher: United States
DOI: 10.1097/ICO.0000000000000170
PMID: 24915017
ISSN: 0277-3740
eISSN: 1536-4798
Language: English
Date published: 08/2014
Academic Unit: Biostatistics; Ophthalmology and Visual Sciences
Record Identifier: 9983979992202771

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