Journal article
Granulocyte Colony‐Stimulating Factor Modulates the Pulmonary Host Response to Endotoxin in the Absence and Presence of Acute Ethanol Intoxication
The Journal of infectious diseases, Vol.179(6), pp.1441-1448
06/1999
DOI: 10.1086/314763
PMID: 10228066
Abstract
Alcohol impairs neutrophil function and predisposes the host to infectious complications. Granulocyte colony-stimulating factor (G-CSF) increases both the number and functional activities of neutrophils. This study investigated the effects of G-CSF on the pulmonary response to endotoxin in rats with or without acute ethanol intoxication. Acute ethanol intoxication inhibited tumor necrosis factor (TNF)-alpha and macrophage inflammatory protein (MIP)-2 production in the lung and suppressed the recruitment of neutrophils into the lung. Ethanol also inhibited CD11b/c expression on recruited neutrophils and suppressed the phagocytic activity of circulating neutrophils. G-CSF pretreatment up-regulated CD11b/c expression on circulating polymorphonuclear leukocytes, augmented the recruitment of neutrophils into the lung, and enhanced the phagocytic activity of circulating and recruited neutrophils in both the absence and presence of acute ethanol intoxication. G-CSF inhibited MIP-2 but not TNF-alpha production in the lung. These data suggest that G-CSF may be useful in the prevention or treatment of infections in persons immunocompromised by alcohol.
Details
- Title: Subtitle
- Granulocyte Colony‐Stimulating Factor Modulates the Pulmonary Host Response to Endotoxin in the Absence and Presence of Acute Ethanol Intoxication
- Creators
- Ping ZhangGregory J BagbyDavid A StoltzWarren R SummerSteve Nelson
- Resource Type
- Journal article
- Publication Details
- The Journal of infectious diseases, Vol.179(6), pp.1441-1448
- DOI
- 10.1086/314763
- PMID
- 10228066
- ISSN
- 0022-1899
- eISSN
- 1537-6613
- Language
- English
- Date published
- 06/1999
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Molecular Physiology and Biophysics; Pulmonary, Critical Care, and Occupational Medicine; Internal Medicine
- Record Identifier
- 9984025591202771
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