Journal article
Granulocyte-Macrophage Colony-Stimulating Factor Induces Modest Increases in Plasma Human Immunodeficiency Virus (HIV) Type 1 RNA Levels and CD4+ Lymphocyte Counts in Patients with Uncontrolled HIV Infection
The Journal of infectious diseases, Vol.188(12), pp.1804-1814
12/15/2003
DOI: 10.1086/379899
PMID: 14673758
Abstract
BackgroundStudies have reported that plasma human immunodeficiency virus type 1 (HIV-1) RNA levels and CD4+ lymphocyte counts in HIV-infected patients improved after treatment with granulocyte-macrophage colony-stimulating factor (GM-CSF)
MethodsIn AIDS Clinical Trials Group Protocol 5041, 116 patients were enrolled in a double-blind, randomized, placebo-controlled clinical trial of 16 weeks of 250 μg of GM-CSF administered subcutaneously 3 times/week, followed by open-label treatment for an additional 32 weeks. Patients had stable baseline plasma HIV-1 RNA levels of ⩾1500 copies/mL and received constant antiretroviral regimens through at least the first 16 weeks of the study
ResultsAfter 16 weeks, the GM-CSF group tended to have greater, though clinically insignificant, increases in plasma HIV-1 RNA levels, compared with the placebo group (median change, +0.048 vs. −0.103 log copies/mL; P=.036, in a post hoc analysis). There were trends toward progressive modest increases in CD4+ lymphocyte counts with GM-CSF treatment at 16 weeks (median change, +14 vs. −6 cells/mm3; P=.06) and beyond
ConclusionsGM-CSF does not have an antiviral effect in patients with ongoing HIV replication but may increase CD4+ lymphocyte counts
Details
- Title: Subtitle
- Granulocyte-Macrophage Colony-Stimulating Factor Induces Modest Increases in Plasma Human Immunodeficiency Virus (HIV) Type 1 RNA Levels and CD4+ Lymphocyte Counts in Patients with Uncontrolled HIV Infection
- Creators
- Jeffrey M Jacobson - 1Department of Medicine, Beth Israel Medical Center and Albert Einstein College of Medicine, andMichael M Lederman - 1Department of Medicine, Beth Israel Medical Center and Albert Einstein College of Medicine, andJohn Spritzler - 1Department of Medicine, Beth Israel Medical Center and Albert Einstein College of Medicine, andHernan Valdez - 1Department of Medicine, Beth Israel Medical Center and Albert Einstein College of Medicine, andPablo Tebas - 1Department of Medicine, Beth Israel Medical Center and Albert Einstein College of Medicine, andGail Skowron - 1Department of Medicine, Beth Israel Medical Center and Albert Einstein College of Medicine, andRui Wang - 1Department of Medicine, Beth Israel Medical Center and Albert Einstein College of Medicine, andJ. Brooks Jackson - 1Department of Medicine, Beth Israel Medical Center and Albert Einstein College of Medicine, andLawrence Fox - 1Department of Medicine, Beth Israel Medical Center and Albert Einstein College of Medicine, andAlan Landay - 1Department of Medicine, Beth Israel Medical Center and Albert Einstein College of Medicine, andMark J Gilbert - 1Department of Medicine, Beth Israel Medical Center and Albert Einstein College of Medicine, andDorothy O'Neil - 1Department of Medicine, Beth Israel Medical Center and Albert Einstein College of Medicine, andLynne Bancroft - 1Department of Medicine, Beth Israel Medical Center and Albert Einstein College of Medicine, andLena Al-Harthi - 1Department of Medicine, Beth Israel Medical Center and Albert Einstein College of Medicine, andMark A Jacobson - 1Department of Medicine, Beth Israel Medical Center and Albert Einstein College of Medicine, andThomas C Merigan - 1Department of Medicine, Beth Israel Medical Center and Albert Einstein College of Medicine, and
- Resource Type
- Journal article
- Publication Details
- The Journal of infectious diseases, Vol.188(12), pp.1804-1814
- Publisher
- The University of Chicago Press
- DOI
- 10.1086/379899
- PMID
- 14673758
- ISSN
- 0022-1899
- eISSN
- 1537-6613
- Language
- English
- Date published
- 12/15/2003
- Academic Unit
- Pathology; VPMA - Administration
- Record Identifier
- 9984047874602771
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