Journal article
Gray Matter Nucleus Hyperintensity After Monthly Triple-Dose Gadopentetate Dimeglumine With Long-term Magnetic Resonance Imaging
Investigative radiology, Vol.55(10), pp.629-635
10/2020
DOI: 10.1097/RLI.0000000000000663
PMID: 32898355
Abstract
Gadolinium deposition is widely believed to occur, but questions regarding accumulation pattern and permanence remain. We conducted a retrospective study of intracranial signal changes on monthly triple-dose contrast-enhanced magnetic resonance imaging (MRI) examinations from the previously published Betaseron vs. Copaxone in Multiple Sclerosis With Triple-Dose Gadolinium and 3-Tesla MRI Endpoints Trial (N = 67) to characterize the dynamics of gadolinium deposition in several deep brain nuclei and track persistence versus washout of gadolinium deposition on long-term follow-up (LTFU) examinations (N = 28) obtained approximately 10 years after enrollment in the Betaseron vs. Copaxone in Multiple Sclerosis With Triple-Dose Gadolinium and 3-Tesla MRI Endpoints Trial.
Using T2 and proton density images and using image analysis software (ITK-SNAP), manual regions of interest were created ascribing boundaries of the caudate nucleus, dentate nucleus, globus pallidus, pulvinar, putamen, white matter, and air. Intensity analysis was conducted on T1-weighted fat-saturated (fat-sat) images using the FSL package. A linear rigid-body transform was calculated from the fat-sat image at each target time point to the region of interest segmentation reference time point fat-sat image. Serial MRI signal was analyzed using linear mixed regression modeling with random intercept. Annual MRI signal changes including LTFU scans were assessed with t test.
During monthly scanning, all gray matter structures demonstrated a significant (P < 0.0001) increase in contrast-to-noise ratio. Yearly changes in deposition showed distinctive patterns for the specific nucleus: globus pallidus showed complete retention, pulvinar showed partial washout, while dentate, caudate, and putamen returned to baseline (ie, complete washout).
Monthly increased contrast-to-noise ratio in gray matter nuclei is consistent with gadolinium deposition over time. The study also suggests that some deep gray matter nuclei permanently retain gadolinium, whereas others demonstrate washout of soluble gadolinium.
Details
- Title: Subtitle
- Gray Matter Nucleus Hyperintensity After Monthly Triple-Dose Gadopentetate Dimeglumine With Long-term Magnetic Resonance Imaging
- Creators
- John J DeBevits IV - From the University of Connecticut, School of Medicine, Farmington, CTReshma Munbodh - Brown UniversityDevin Bageac - University of ConnecticutRong Wu - University of ConnecticutPaul A DiCamillo - University of IowaChaoran Hu - University of ConnecticutLihong Wang - University of ConnecticutRobert T Naismith - NeurologyDavid Karimeddini - University of ConnecticutSuhayl Dhib-Jalbut - Rutgers, The State University of New JerseySviatoslav Redko - Rutgers, The State University of New JerseyStuart D Cook - Rutgers, The State University of New JerseyDiego Cadavid - University of Massachusetts Medical SchoolLeo Wolansky - University of Connecticut
- Resource Type
- Journal article
- Publication Details
- Investigative radiology, Vol.55(10), pp.629-635
- DOI
- 10.1097/RLI.0000000000000663
- PMID
- 32898355
- ISSN
- 0020-9996
- eISSN
- 1536-0210
- Language
- English
- Date published
- 10/2020
- Academic Unit
- Radiology
- Record Identifier
- 9984318723402771
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