Journal article
Gray matter atrophy in patients with mild cognitive impairment/Alzheimer's disease over the course of developing delusions
International journal of geriatric psychiatry, Vol.31(1), pp.76-82
01/2016
DOI: 10.1002/gps.4291
PMCID: PMC5963287
PMID: 25821062
Abstract
We conducted a neuroimaging analysis to understand the neuroanatomical correlates of gray matter loss in a group of mild cognitive impairment and early Alzheimer's disease patients who developed delusions.
With data collected as part of the Alzheimer's Disease Neuroimaging Initiative, we conducted voxel-based morphometry to determine areas of gray matter change in the same Alzheimer's Disease Neuroimaging Initiative participants, before and after they developed delusions.
We identified 14 voxel clusters with significant gray matter decrease in patient scans post-delusional onset, correcting for multiple comparisons (false discovery rate, p < 0.05). Major areas of difference included the right and left insulae, left precuneus, the right and left cerebellar culmen, the left superior temporal gyrus, the right posterior cingulate, the right thalamus, and the left parahippocampal gyrus.
Although contrary to our initial predictions of enhanced right frontal atrophy, our preliminary work identifies several neuroanatomical areas, including the cerebellum and left posterior hemisphere, which may be involved in delusional development in these patients.
Details
- Title: Subtitle
- Gray matter atrophy in patients with mild cognitive impairment/Alzheimer's disease over the course of developing delusions
- Creators
- Corinne E Fischer - Faculty of Medicine, Department of Psychiatry, University of Toronto, Toronto, ON, CanadaWindsor Kwan-Chun Ting - Keenan Research Centre for Biomedical Science, The Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON, CanadaColleen P Millikin - Department of Clinical Health Psychology, College of Medicine, Health Sciences, University of Manitoba, Winnipeg, MB, CanadaZahinoor Ismail - Hotchkiss Brain Institute, Calgary, AB, CanadaTom A Schweizer - Division of Neurosurgery, St. Michael's Hospital, Toronto, ON, CanadaAlzheimer Disease Neuroimaging Initiative
- Contributors
- Laura L Boles-Ponto (Contributor) - University of Iowa, Radiology
- Resource Type
- Journal article
- Publication Details
- International journal of geriatric psychiatry, Vol.31(1), pp.76-82
- Publisher
- England
- DOI
- 10.1002/gps.4291
- PMID
- 25821062
- PMCID
- PMC5963287
- ISSN
- 0885-6230
- eISSN
- 1099-1166
- Grant note
- Canadian Institutes of Health Research U24 AG021886 / NIA NIH HHS U01 AG024904 / NIA NIH HHS
- Language
- English
- Date published
- 01/2016
- Academic Unit
- Radiology; Pharmaceutical Sciences and Experimental Therapeutics
- Record Identifier
- 9984051567302771
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