Gray matter atrophy in patients with mild cognitive impairment/Alzheimer's disease over the course of developing delusions

Corinne E Fischer; Windsor Kwan-Chun Ting; Colleen P Millikin; Zahinoor Ismail; Tom A Schweizer; Alzheimer Disease Neuroimaging Initiative

doi:10.1002/gps.4291

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Gray matter atrophy in patients with mild cognitive impairment/Alzheimer's disease over the course of developing delusions

Journal article

Peer reviewed

Gray matter atrophy in patients with mild cognitive impairment/Alzheimer's disease over the course of developing delusions

Corinne E Fischer, Windsor Kwan-Chun Ting, Colleen P Millikin, Zahinoor Ismail, Tom A Schweizer and Alzheimer Disease Neuroimaging Initiative

International journal of geriatric psychiatry, Vol.31(1), pp.76-82

01/2016

DOI: 10.1002/gps.4291

PMCID: PMC5963287

PMID: 25821062

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Abstract

We conducted a neuroimaging analysis to understand the neuroanatomical correlates of gray matter loss in a group of mild cognitive impairment and early Alzheimer's disease patients who developed delusions. With data collected as part of the Alzheimer's Disease Neuroimaging Initiative, we conducted voxel-based morphometry to determine areas of gray matter change in the same Alzheimer's Disease Neuroimaging Initiative participants, before and after they developed delusions. We identified 14 voxel clusters with significant gray matter decrease in patient scans post-delusional onset, correcting for multiple comparisons (false discovery rate, p < 0.05). Major areas of difference included the right and left insulae, left precuneus, the right and left cerebellar culmen, the left superior temporal gyrus, the right posterior cingulate, the right thalamus, and the left parahippocampal gyrus. Although contrary to our initial predictions of enhanced right frontal atrophy, our preliminary work identifies several neuroanatomical areas, including the cerebellum and left posterior hemisphere, which may be involved in delusional development in these patients.

Neuroimaging - methods

Humans

Magnetic Resonance Imaging - methods

Delusions - pathology

Male

Brain Mapping - methods

Cognitive Dysfunction - pathology

Alzheimer Disease - pathology

Atrophy

Image Processing, Computer-Assisted

Gray Matter - pathology

Aged, 80 and over

Cognitive Dysfunction - psychology

Female

Aged

Alzheimer Disease - psychology

Details

Title: Subtitle: Gray matter atrophy in patients with mild cognitive impairment/Alzheimer's disease over the course of developing delusions
Creators: Corinne E Fischer - Faculty of Medicine, Department of Psychiatry, University of Toronto, Toronto, ON, Canada
Windsor Kwan-Chun Ting - Keenan Research Centre for Biomedical Science, The Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON, Canada
Colleen P Millikin - Department of Clinical Health Psychology, College of Medicine, Health Sciences, University of Manitoba, Winnipeg, MB, Canada
Zahinoor Ismail - Hotchkiss Brain Institute, Calgary, AB, Canada
Tom A Schweizer - Division of Neurosurgery, St. Michael's Hospital, Toronto, ON, Canada
Alzheimer Disease Neuroimaging Initiative
Contributors: Laura L Boles-Ponto (Contributor) - University of Iowa, Radiology
Resource Type: Journal article
Publication Details: International journal of geriatric psychiatry, Vol.31(1), pp.76-82
DOI: 10.1002/gps.4291
PMID: 25821062
PMCID: PMC5963287
NLM abbreviation: Int J Geriatr Psychiatry
ISSN: 0885-6230
eISSN: 1099-1166
Publisher: England
Grant note: Canadian Institutes of Health Research U24 AG021886 / NIA NIH HHS U01 AG024904 / NIA NIH HHS
Language: English
Date published: 01/2016
Academic Unit: Radiology; Pharmaceutical Sciences and Experimental Therapeutics
Record Identifier: 9984051567302771

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