Greater Apparent Absorption of Flavonoids Is Associated with Lesser Human Fecal Flavonoid Disappearance Rates

Andrean L SIMONS; Mathieu RENOUF; Patricia A MURPHY; Suzanne HENDRICH

doi:10.1021/jf902284u

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Greater Apparent Absorption of Flavonoids Is Associated with Lesser Human Fecal Flavonoid Disappearance Rates

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Greater Apparent Absorption of Flavonoids Is Associated with Lesser Human Fecal Flavonoid Disappearance Rates

Andrean L SIMONS, Mathieu RENOUF, Patricia A MURPHY and Suzanne HENDRICH

Journal of agricultural and food chemistry, Vol.58(1), pp.141-147

2010

DOI: 10.1021/jf902284u

PMID: 19921837

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Abstract

It was hypothesized that 5,7,4'-OH-flavonoids disappeared more rapidly from human fecal incubations and were less absorbable by humans than flavonoids without 5-OH moieties. Anaerobic fecal disappearance rates over 24 h were determined for 15 flavonoids in samples from 20 men and 13 women. In these anaerobic fecal mixtures, flavonoids with 5,7,4'-OH groups, genistein, apigenin, naringenin, luteolin, kaempferol, and quercetin (disappearance rate, k=0.46+/-0.10 h(-1)), and methoxylated flavonoids, hesperetin and glycitein (k=0.24+/-0.21 h(-1)), disappeared rapidly compared with flavonoids lacking 5-OH (e.g., daidzein, k=0.07+/-0.03 h(-1)). Apparent absorption of flavonoids that disappeared rapidly from in vitro fecal incubations, genistein, naringenin, quercetin, and hesperetin, was compared with that of daidzein, a slowly disappearing flavonoid, in 5 men and 5 women. Subjects ingested 104 micromol of genistein and 62 micromol of daidzein (soy milk), 1549 micromol of naringenin and 26 micromol of hesperetin (grapefruit juice), and 381 micromol of quercetin (onions) in three test meals, each separated by 1 week. Blood and urine samples were collected over 24 h after each test meal. Plasma flavonoid concentrations ranged from 0.01 to 1 microM. The apparent absorption, expressed as percentage of ingested dose excreted in urine, was significantly less for naringenin (3.2+/-1.7%), genistein (7.2+/-4.6%), hesperetin (7.3+/-3.2%), and quercetin (5.6+/-3.7%) compared with daidzein (43.4+/-15.5%, p=0.02). These data affirmed the hypothesis that the 5,7,4'-OH of flavonoids limited apparent absorption of these compounds in humans.

Fundamental and applied biological sciences. Psychology

Feeding. Feeding behavior

Food industries

Biological and medical sciences

Vertebrates: anatomy and physiology, studies on body, several organs or systems

Details

Title: Subtitle: Greater Apparent Absorption of Flavonoids Is Associated with Lesser Human Fecal Flavonoid Disappearance Rates
Creators: Andrean L SIMONS - Department of Food Science and Human Nutrition, Iowa State University, Ames, Iowa 50011, United States
Mathieu RENOUF - Department of Food Science and Human Nutrition, Iowa State University, Ames, Iowa 50011, United States
Patricia A MURPHY - Department of Food Science and Human Nutrition, Iowa State University, Ames, Iowa 50011, United States
Suzanne HENDRICH - Department of Food Science and Human Nutrition, Iowa State University, Ames, Iowa 50011, United States
Resource Type: Journal article
Publication Details: Journal of agricultural and food chemistry, Vol.58(1), pp.141-147
DOI: 10.1021/jf902284u
PMID: 19921837
NLM abbreviation: J Agric Food Chem
ISSN: 0021-8561
eISSN: 1520-5118
Publisher: American Chemical Society; Washington, DC
Language: English
Date published: 2010
Academic Unit: Oral Pathology, Radiology and Medicine; Pathology; Pharmaceutical Sciences and Experimental Therapeutics; Radiation Oncology
Record Identifier: 9984047797102771

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