Journal article
Greater Number of Plasma Exchanges Does Not Improve Outcome in Myasthenic Crisis
Journal of clinical neuromuscular disease, Vol.24(4), pp.199-206
06/01/2023
DOI: 10.1097/CND.0000000000000421
PMID: 37219863
Abstract
Objectives:
To determine the relationship between the number of plasma exchanges and clinical outcome in patients experiencing myasthenic crisis.
Methods:
We retrospectively reviewed all episodes of myasthenia gravis exacerbation/crisis who received plasmapheresis in patients admitted to a single-center tertiary care referral center from July 2008 to July 2017. We performed statistical analyses to determine whether the increased number of plasma exchanges improves the primary outcome (hospital length of stay) and the secondary outcome (disposition to home, skilled nursing facility, long-term acute care hospital, or death).
Results:
There is neither clinically observable nor statistically significant improvement in length of stay or disposition on discharge in patients who received 6 or greater sessions of plasmapheresis.
Conclusions:
This study provides class IV evidence that extending the number of plasma exchanges beyond 5 does not correlate with decreased hospital length of stay or improved discharge disposition in patients experiencing myasthenic crisis.
Details
- Title: Subtitle
- Greater Number of Plasma Exchanges Does Not Improve Outcome in Myasthenic Crisis
- Creators
- Michael Hansen - University Hospitals Cleveland Medical CenterLee Neilson - University Hospitals Cleveland Medical CenterMelanie Parikh - University Hospitals Cleveland Medical CenterBashar Katirji - University Hospitals Cleveland Medical Center
- Resource Type
- Journal article
- Publication Details
- Journal of clinical neuromuscular disease, Vol.24(4), pp.199-206
- DOI
- 10.1097/CND.0000000000000421
- PMID
- 37219863
- NLM abbreviation
- J Clin Neuromuscul Dis
- ISSN
- 1522-0443
- eISSN
- 1537-1611
- Number of pages
- 8
- Grant note
- VA Parkinson Disease Research, Education and Clinical Centers U.S. Department of Veterans Affairs (http://data.elsevier.com/vocabulary/SciValFunders/100000738) PADRECC
- Language
- English
- Date published
- 06/01/2023
- Academic Unit
- Neurology
- Record Identifier
- 9985089127002771
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