Greater Reduction in Contralesional Hand Use After Frontoparietal Than Frontal Motor Cortex Lesions in Macaca mulatta

Warren G Darling; Marc A Pizzimenti; Diane L Rotella; Jizhi Ge; Kimberly S Stilwell-Morecraft; Robert J Morecraft

doi:10.3389/fnsys.2021.592235

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Greater Reduction in Contralesional Hand Use After Frontoparietal Than Frontal Motor Cortex Lesions in Macaca mulatta

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Greater Reduction in Contralesional Hand Use After Frontoparietal Than Frontal Motor Cortex Lesions in Macaca mulatta

Warren G Darling, Marc A Pizzimenti, Diane L Rotella, Jizhi Ge, Kimberly S Stilwell-Morecraft and Robert J Morecraft

Frontiers in systems neuroscience, Vol.15, pp.592235-592235

03/18/2021

DOI: 10.3389/fnsys.2021.592235

PMCID: PMC8012777

PMID: 33815072

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Abstract

We previously reported that rhesus monkeys recover spontaneous use of the more impaired (contralesional) hand following neurosurgical lesions to the arm/hand representations of primary motor cortex (M1) and lateral premotor cortex (LPMC) (F2 lesion) when tested for reduced use (RU) in a fine motor task allowing use of either hand. Recovery occurred without constraint of the less impaired hand and with occasional forced use of the more impaired hand, which was the preferred hand for use in fine motor tasks before the lesion. Here, we compared recovery of five F2 lesion cases in the same RU test to recovery after unilateral lesions of M1, LPMC, S1 and anterior portion of parietal cortex (F2P2 lesion – four cases). Average and highest %use of the contralesional hand in the RU task in F2 cases were twice that in F2P2 cases ( p < 0.05). Recovery in the RU task was closely associated with volume and percentage of lesion to caudal (new) M1 (M1c) in both F2 and F2P2 lesion cases. One F2P2 case, with the largest M1c lesion and a large rostral somatosensory cortex (S1r) lesion developed severe contralesional hand non-use despite exhibiting some recovery of fine motor function initially. We conclude that the degree of reduced use of the contralesional hand is primarily related to the volume of M1c injury and that severe non-use requires extensive injury to M1c and S1r. Thus, assessing peri-Rolandic injury extent in stroke patients may have prognostic value for predicting susceptibility to RU and non-use in rehabilitation.

brain injury

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Details

Title: Subtitle: Greater Reduction in Contralesional Hand Use After Frontoparietal Than Frontal Motor Cortex Lesions in Macaca mulatta
Creators: Warren G Darling - University of Iowa
Marc A Pizzimenti - Roy J. and Lucille A. Carver College of Medicine
Diane L Rotella - University of Iowa
Jizhi Ge - University of South Dakota
Kimberly S Stilwell-Morecraft - University of South Dakota
Robert J Morecraft - University of South Dakota
Resource Type: Journal article
Publication Details: Frontiers in systems neuroscience, Vol.15, pp.592235-592235
DOI: 10.3389/fnsys.2021.592235
PMID: 33815072
PMCID: PMC8012777
NLM abbreviation: Front Syst Neurosci
ISSN: 1662-5137
eISSN: 1662-5137
Publisher: Frontiers Media S.A
Grant note: National Institute of Neurological Disorders and Stroke
Language: English
Date published: 03/18/2021
Academic Unit: Anatomy and Cell Biology; Physical Therapy and Rehabilitation Science; Health, Sport, and Human Physiology
Record Identifier: 9984259658902771

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