Journal article
Greater glucose uptake heterogeneity in knee muscles of old compared to young men during isometric contractions detected by [18F]-FDG PET/CT
Frontiers in physiology, Vol.5, pp.198-198
2014
DOI: 10.3389/fphys.2014.00198
PMID: 24904432
Abstract
We used positron emission tomography/computed tomography (PET/CT) and [
18
F]-FDG to test the hypothesis that glucose uptake (GU) heterogeneity in skeletal muscles as a measure of heterogeneity in muscle activity is greater in old than young men when they perform isometric contractions. Six young (26 ± 6 years) and six old (77 ± 6 years) men performed two types of submaximal isometric contractions that required either force or position control. [
18
F]-FDG was injected during the task and PET/CT scans were performed immediately after the task. Within-muscle heterogeneity of knee muscles was determined by calculating the coefficient of variation (CV) of GU in PET image voxels within the muscles of interest. The average GU heterogeneity (mean ± SD) for knee extensors and flexors was greater for the old (35.3 ± 3.3%) than the young (28.6 ± 2.4%) (
P
= 0.006). Muscle volume of the knee extensors were greater for the young compared to the old men (1016 ± 163 vs. 598 ± 70 cm
3
,
P
= 0.004). In a multiple regression model, knee extensor muscle volume was a predictor (partial
r
= −0.87;
P
= 0.001) of GU heterogeneity for old men (
R
2
= 0.78;
P
< 0.001), and MVC force predicted GU heterogeneity for young men (partial
r
= −0.95,
P
< 0.001). The findings demonstrate that GU is more spatially variable for old than young men and especially so for old men who exhibit greater muscle atrophy.
Details
- Title: Subtitle
- Greater glucose uptake heterogeneity in knee muscles of old compared to young men during isometric contractions detected by [18F]-FDG PET/CT
- Creators
- Thorsten Rudroff - Integrative Neurophysiology Laboratory, Department of Health and Exercise Science, Colorado State UniversityJohn H Kindred - Integrative Neurophysiology Laboratory, Department of Health and Exercise Science, Colorado State UniversityJohn-Michael Benson - Integrative Neurophysiology Laboratory, Department of Health and Exercise Science, Colorado State UniversityBrian L Tracy - Integrative Neurophysiology Laboratory, Department of Health and Exercise Science, Colorado State UniversityKari K Kalliokoski - Turku PET Centre, University of Turku and Turku University Hospital
- Resource Type
- Journal article
- Publication Details
- Frontiers in physiology, Vol.5, pp.198-198
- DOI
- 10.3389/fphys.2014.00198
- PMID
- 24904432
- NLM abbreviation
- Front Physiol
- ISSN
- 1664-042X
- eISSN
- 1664-042X
- Publisher
- Frontiers Media S.A
- Language
- English
- Date published
- 2014
- Academic Unit
- Neurology; Health, Sport, and Human Physiology
- Record Identifier
- 9984002489402771
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