Journal article
Group B Streptococcus Infection in Extremely Preterm Neonates and Neurodevelopmental Outcomes at 2 Years
Clinical infectious diseases, Vol.75(8), pp.1405-1415
10/12/2022
DOI: 10.1093/cid/ciac222
PMCID: PMC9555845
PMID: 35323895
Abstract
This study was performed to determine the incidence of group B Streptococcus (GBS) disease among extremely preterm infants and assess to risk of death or neurodevelopmental impairment (NDI) at a corrected age of 18-26 months.
In this observational cohort study of infants enrolled in a multicenter registry, the incidence of GBS disease was assessed in infants born in 1998-2016 at 22-28 weeks' gestation and surviving for >12 hours. The composite outcome, death or NDI, was assessed in infants born in 1998-2014 at 22-26 weeks' gestation. Infection was defined as GBS isolation in blood or cerebrospinal fluid culture at ≤72 hours (early-onset disease [EOD]) or >72 hours (late-onset disease [LOD]) after birth. Using Poisson regression models, the outcome was compared in infants with GBS disease, infants infected with other pathogens, and uninfected infants.
The incidence of GBS EOD (2.70/1000 births [95% confidence interval (CI), 2.15-3.36]) and LOD (8.47/1000 infants [7.45-9.59]) did not change significantly over time. The adjusted relative risk of death/NDI was higher among infants with GBS EOD than in those with other infections (adjusted relative risk, 1.22 [95% CI, 1.02-1.45]) and uninfected infants (1.44 [1.23-1.69]). Risk of death/NDI did not differ between infants with GBS LOD and comparator groups. GBS LOD occurred at a significantly later age than non-GBS late-onset infection. Among infants surviving >30 days, the risk of death was higher with GBS LOD (adjusted relative risk, 1.90 [95% CI, 1.36-2.67]), compared with uninfected infants.
In a cohort of extremely preterm infants, the incidence of GBS disease did not change during the study period. The increased risk of death or NDI with GBS EOD, and of death among some infants with GBS LOD, supports the need for novel preventive strategies for disease reduction.
NCT00063063.
Details
- Title: Subtitle
- Group B Streptococcus Infection in Extremely Preterm Neonates and Neurodevelopmental Outcomes at 2 Years
- Creators
- Karen M Puopolo - Children's Hospital of PhiladelphiaSagori Mukhopadhyay - Children's Hospital of PhiladelphiaNellie I Hansen - RTI InternationalDustin D Flannery - Children's Hospital of PhiladelphiaRachel G Greenberg - Duke UniversityPablo J Sanchez - The Ohio State UniversityEdward F Bell - University of IowaSara B DeMauro - Children's Hospital of PhiladelphiaMyra H Wyckoff - The University of Texas Southwestern Medical CenterEric C Eichenwald - Children's Hospital of PhiladelphiaBarbara J Stoll - The University of Texas Health Science CenterEunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network
- Resource Type
- Journal article
- Publication Details
- Clinical infectious diseases, Vol.75(8), pp.1405-1415
- DOI
- 10.1093/cid/ciac222
- PMID
- 35323895
- PMCID
- PMC9555845
- ISSN
- 1058-4838
- eISSN
- 1537-6591
- Grant note
- U10 HD21373 / Eunice Kennedy Shriver National Institute of Child Health and Human Development UL1 TR6 / NCATS NIH HHS
- Language
- English
- Date published
- 10/12/2022
- Academic Unit
- Stead Family Department of Pediatrics; Neonatology
- Record Identifier
- 9984353881602771
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