Journal article
Group D Adenoviruses Infect Primary Central Nervous System Cells More Efficiently than Those from Group C
Journal of virology, Vol.73(3), pp.2537-2540
Note
03/1999
DOI: 10.1128/JVI.73.3.2537-2540.1999
PMCID: PMC104501
PMID: 9971839
Abstract
Group C adenovirus-mediated gene transfer to central nervous system cells is inefficient. We found that wild-type group D viruses, or recombinant adenovirus type 2 (Ad2) (group C) modified to contain Ad17 (group D) fiber, were more efficient in infecting primary cultures of neurons. Together with studies on primary vascular endothelial cells and tissue culture cell lines, our results indicate that there is not a universally applicable adenovirus serotype for use as a gene transfer vector.
Details
- Title: Subtitle
- Group D Adenoviruses Infect Primary Central Nervous System Cells More Efficiently than Those from Group C
- Creators
- Miguel Chillon - The Department of Internal MedicineAssumpció Bosch - The Department of Internal MedicineJoseph Zabner - The Department of Internal MedicineLane Law - The Department of Internal MedicineDonna Armentano - The Department of Internal MedicineMichael J Welsh - The Department of Internal MedicineBeverly L Davidson - The Department of Internal Medicine
- Resource Type
- Journal article
- Publication Details
- Journal of virology, Vol.73(3), pp.2537-2540
- Publisher
- American Society for Microbiology
- Series
- Note
- DOI
- 10.1128/JVI.73.3.2537-2540.1999
- PMID
- 9971839
- PMCID
- PMC104501
- ISSN
- 0022-538X
- eISSN
- 1098-5514
- Language
- English
- Date published
- 03/1999
- Academic Unit
- Neurology; Molecular Physiology and Biophysics; Pulmonary, Critical Care, and Occupational Medicine; Neurosurgery; Internal Medicine
- Record Identifier
- 9984020867402771
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