Journal article
Growth Outcomes of Preterm Infants Exposed to Different Oxygen Saturation Target Ranges from Birth
The Journal of pediatrics, Vol.176, pp.62-68.e4
09/2016
DOI: 10.1016/j.jpeds.2016.05.070
PMCID: PMC5327617
PMID: 27344218
Abstract
To test whether infants randomized to a lower oxygen saturation (peripheral capillary oxygen saturation [SpO2]) target range while on supplemental oxygen from birth will have better growth velocity from birth to 36 weeks postmenstrual age (PMA) and less growth failure at 36 weeks PMA and 18-22 months corrected age.
We evaluated a subgroup of 810 preterm infants from the Surfactant, Positive Pressure, and Oxygenation Randomized Trial, randomized at birth to lower (85%-89%, n = 402, PMA 26 ± 1 weeks, birth weight 839 ± 186 g) or higher (91%-95%, n = 408, PMA 26 ± 1 weeks, birth weight 840 ± 191 g) SpO2 target ranges. Anthropometric measures were obtained at birth, postnatal days 7, 14, 21, and 28; then at 32 and 36 weeks PMA; and 18-22 months corrected age. Growth velocities were estimated with the exponential method and analyzed with linear mixed models. Poor growth outcome, defined as weight <10th percentile at 36 weeks PMA and 18-22 months corrected age, was compared across the 2 treatment groups by the use of robust Poisson regression.
Growth outcomes including growth at 36 weeks PMA and 18-22 months corrected age, as well as growth velocity were similar in the lower and higher SpO2 target groups.
Targeting different oxygen saturation ranges between 85% and 95% from birth did not impact growth velocity or reduce growth failure in preterm infants.
Details
- Title: Subtitle
- Growth Outcomes of Preterm Infants Exposed to Different Oxygen Saturation Target Ranges from Birth
- Creators
- Cristina T Navarrete - University of Miami Miller School of Medicine, Miami, FL. Electronic address: cnavarrete@med.miami.eduLisa A Wrage - Social, Statistical and Environmental Sciences Unit, RTI International, Research Triangle Park, NCWaldemar A Carlo - Division of Neonatology, University of Alabama at Birmingham, Birmingham, ALMichele C Walsh - Department of Pediatrics, Rainbow Babies & Children's Hospital, Case Western Reserve University, Cleveland, OHWade Rich - Division of Neonatology, University of California San Diego, San Diego, CAMarie G Gantz - Social, Statistical and Environmental Sciences Unit, RTI International, Research Triangle Park, NCAbhik Das - Social, Statistical and Environmental Sciences Unit, RTI International, Rockville, MDKurt Schibler - Department of Pediatrics, Cincinnati Children's Hospital Medical Center and University of Cincinnati, Cincinnati, OHNancy S Newman - Division of Neonatology, University of California San Diego, San Diego, CAAnthony J Piazza - Department of Pediatrics, Emory University School of Medicine, and Children's Healthcare of Atlanta, Atlanta, GABrenda B Poindexter - Department of Pediatrics, Indiana University School of Medicine, Indianapolis, INSeetha Shankaran - Department of Pediatrics, Wayne State University, Detroit, MIPablo J Sánchez - Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TXBrenda H Morris - Department of Pediatrics, University of Texas Medical School at Houston, Houston, TXIvan D Frantz III - Division of Newborn Medicine, Department of Pediatrics, Floating Hospital for Children, Tufts Medical Center, Boston, MAKrisa P Van Meurs - Division of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University School of Medicine and Lucile Packard Children's Hospital, Palo Alto, CAC Michael Cotten - Department of Pediatrics, Duke University, Durham, NCRichard A Ehrenkranz - Department of Pediatrics, Yale University School of Medicine, New Haven, CTEdward F Bell - Department of Pediatrics, University of Iowa, Iowa City, IAKristi L Watterberg - University of New Mexico Health Sciences Center, Albuquerque, NMRosemary D Higgins - Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MDShahnaz Duara - University of Miami Miller School of Medicine, Miami, FLEunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network
- Resource Type
- Journal article
- Publication Details
- The Journal of pediatrics, Vol.176, pp.62-68.e4
- DOI
- 10.1016/j.jpeds.2016.05.070
- PMID
- 27344218
- PMCID
- PMC5327617
- NLM abbreviation
- J Pediatr
- ISSN
- 0022-3476
- eISSN
- 1097-6833
- Publisher
- Elsevier BV
- Grant note
- UG1 HD053089 / NICHD NIH HHS UG1 HD027851 / NICHD NIH HHS UG1 HD040492 / NICHD NIH HHS U10 HD027871 / NICHD NIH HHS U10 HD053119 / NICHD NIH HHS UG1 HD027880 / NICHD NIH HHS UG1 HD053109 / NICHD NIH HHS U10 HD021373 / NICHD NIH HHS U10 HD040492 / NICHD NIH HHS U10 HD021397 / NICHD NIH HHS U10 HD036790 / NICHD NIH HHS U10 HD053089 / NICHD NIH HHS UL1 TR001863 / NCATS NIH HHS U10 HD040689 / NICHD NIH HHS U10 HD053109 / NICHD NIH HHS U10 HD027856 / NICHD NIH HHS U10 HD027880 / NICHD NIH HHS U10 HD027853 / NICHD NIH HHS U10 HD021364 / NICHD NIH HHS U10 HD027851 / NICHD NIH HHS U10 HD034216 / NICHD NIH HHS U10 HD021385 / NICHD NIH HHS UG1 HD034216 / NICHD NIH HHS UG1 HD021364 / NICHD NIH HHS UG1 HD027853 / NICHD NIH HHS UG1 HD068278 / NICHD NIH HHS
- Language
- English
- Date published
- 09/2016
- Academic Unit
- Stead Family Department of Pediatrics; Neonatology
- Record Identifier
- 9984093360902771
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