Growth Rates of Infants Randomized to Continuous Positive Airway Pressure or Intubation After Extremely Preterm Birth

Ariel A Salas; Waldemar A Carlo; Barbara T Do; Edward F Bell; Abhik Das; Krisa P Van Meurs; Brenda B Poindexter; Seetha Shankaran; Noelle Younge; Kristi L Watterberg; Rosemary D Higgins; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network

doi:10.1016/j.jpeds.2021.06.026

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Growth Rates of Infants Randomized to Continuous Positive Airway Pressure or Intubation After Extremely Preterm Birth

Journal article

Open access

Peer reviewed

Growth Rates of Infants Randomized to Continuous Positive Airway Pressure or Intubation After Extremely Preterm Birth

Ariel A Salas, Waldemar A Carlo, Barbara T Do, Edward F Bell, Abhik Das, Krisa P Van Meurs, Brenda B Poindexter, Seetha Shankaran, Noelle Younge, Kristi L Watterberg, …

The Journal of pediatrics, Vol.237, pp.148-153.e3

10/2021

DOI: 10.1016/j.jpeds.2021.06.026

PMCID: PMC8478787

PMID: 34157349

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https://www.ncbi.nlm.nih.gov/pmc/articles/8478787View

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Abstract

To evaluate the effects of early treatment with continuous positive airway pressure (CPAP) on nutritional intake and in-hospital growth rates of extremely preterm (EPT) infants. EPT infants (24 -27 weeks of gestation) enrolled in the Surfactant Positive Airway Pressure and Pulse Oximetry Trial (SUPPORT) were included. EPT infants who died before 36 weeks of postmenstrual age (PMA) were excluded. The growth rates from birth to 36 weeks of PMA and follow-up outcomes at 18-22 months corrected age of EPT infants randomized at birth to either early CPAP (intervention group) or early intubation for surfactant administration (control group) were analyzed. Growth data were analyzed for 810 of 1316 infants enrolled in SUPPORT (414 in the intervention group, 396 in the control group). The median gestational age was 26 weeks, and the mean birth weight was 839 g. Baseline characteristics, total nutritional intake, and in-hospital comorbidities were not significantly different between the 2 groups. In a regression model, growth rates between birth and 36 weeks of PMA, as well as growth rates during multiple intervals from birth to day 7, days 7-14, days 14-21, days 21-28, day 28 to 32 weeks PMA, and 32-36 weeks PMA did not differ between treatment groups. Independent of treatment group, higher growth rates from day 21 to day 28 were associated with a lower risk of having a Bayley-III cognitive score <85 at 18-22 months corrected age (P = .002). EPT infants randomized to early CPAP did not have higher in-hospital growth rates than infants randomized to early intubation.

Child Development - physiology

Continuous Positive Airway Pressure

Energy Intake

Female

Gestational Age

Humans

Infant, Extremely Premature

Infant, Newborn

Intubation, Intratracheal

Male

Neurodevelopmental Disorders - epidemiology

Oximetry

Pulmonary Surfactants - therapeutic use

Respiratory Distress Syndrome, Newborn - mortality

Respiratory Distress Syndrome, Newborn - physiopathology

Respiratory Distress Syndrome, Newborn - therapy

Details

Title: Subtitle: Growth Rates of Infants Randomized to Continuous Positive Airway Pressure or Intubation After Extremely Preterm Birth
Creators: Ariel A Salas - University of Alabama at Birmingham
Waldemar A Carlo - University of Alabama at Birmingham
Barbara T Do - Research Triangle Park Foundation
Edward F Bell - University of Iowa
Abhik Das - Research Triangle Park Foundation
Krisa P Van Meurs - Stanford University
Brenda B Poindexter - Emory University
Seetha Shankaran - Wayne State University
Noelle Younge - Duke University
Kristi L Watterberg - University of New Mexico
Rosemary D Higgins - George Mason University
Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network
Contributors: Tarah T Colaizy (Contributor) - University of Iowa, Neonatology
Jonathan M Klein (Contributor) - University of Iowa, Neonatology
Resource Type: Journal article
Publication Details: The Journal of pediatrics, Vol.237, pp.148-153.e3
DOI: 10.1016/j.jpeds.2021.06.026
PMID: 34157349
PMCID: PMC8478787
NLM abbreviation: J Pediatr
ISSN: 0022-3476
eISSN: 1097-6833
Grant note: UG1 HD068244 / NICHD NIH HHS UG1 HD053089 / NICHD NIH HHS UG1 HD027851 / NICHD NIH HHS UG1 HD040492 / NICHD NIH HHS UG1 HD027904 / NICHD NIH HHS U24 HD095254 / NICHD NIH HHS UG1 HD068284 / NICHD NIH HHS UG1 HD027880 / NICHD NIH HHS UG1 HD053109 / NICHD NIH HHS U10 HD021373 / NICHD NIH HHS K23 HD102554 / NICHD NIH HHS U10 HD036790 / NICHD NIH HHS UL1 TR003167 / NCATS NIH HHS K23 DK120960 / NIDDK NIH HHS UG1 HD068263 / NICHD NIH HHS UG1 HD021385 / NICHD NIH HHS UG1 HD087226 / NICHD NIH HHS U10 HD068284 / NICHD NIH HHS UG1 HD068270 / NICHD NIH HHS UG1 HD087229 / NICHD NIH HHS UG1 HD040689 / NICHD NIH HHS U01 HD036790 / NICHD NIH HHS UG1 HD034216 / NICHD NIH HHS UG1 HD027856 / NICHD NIH HHS UG1 HD021364 / NICHD NIH HHS UG1 HD027853 / NICHD NIH HHS UG1 HD068278 / NICHD NIH HHS
Language: English
Date published: 10/2021
Academic Unit: Stead Family Department of Pediatrics; Neonatology
Record Identifier: 9984353949802771

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