Journal article
Growth and obesity through the first 7 y of life in association with levels of maternal glycemia during pregnancy: a prospective cohort study
The American journal of clinical nutrition, Vol.103(3), pp.794-800
03/2016
DOI: 10.3945/ajcn.115.121780
PMCID: PMC4763496
PMID: 26817507
Abstract
Given the long-term adverse sequelae of childhood obesity, identification of early life factors related to fetal growth and childhood obesity is warranted. Investigation on growth and obesity in early life in association with intrauterine exposure to maternal hyperglycemia, a common metabolic pregnancy complication, is of public health significance and clinical implications.
We investigated the association of fasting plasma glucose (FPG) concentrations during pregnancy with offspring growth and risk of overweight/obesity through age 7 y, after adjustment for confounders, including maternal prepregnancy obesity status.
FPG concentrations at 28 gestational weeks (IQR: 22-32 wk) were extracted from medical records for 661 pregnancies complicated by gestational diabetes mellitus in the Danish National Birth Cohort (1996-2002). Offspring's ponderal index was derived from birth weight and length; age- and sex-specific body mass index (BMI) z scores at 5 mo, 12 mo, and 7 y were calculated based on WHO reference data. Relations between FPG and offspring growth and obesity were assessed by linear and Poisson regression with robust standard errors, adjusting for maternal prepregnancy BMI and sociodemographic and perinatal factors.
At birth, maternal FPG during pregnancy was significantly associated with offspring ponderal index (β = 0.46; 95% CI: 0.14, 0.78 per 1-mmol/L increase) and risk of macrosomia (birth weight >4000 g) (RR = 1.21; 95% CI: 1.07, 1.38 per 1-mmol/L increase). At 7 y, higher maternal FPG concentrations were significantly associated with increased BMI z scores (β = 0.20; 95% CI: 0.04, 0.36) and elevated risk of overweight/obesity (RR = 1.21; 95% CI: 1.01, 1.50). Additional adjustment for birth weight and childhood lifestyle factors did not appreciably alter results. No associations were observed at 5 or 12 mo.
Among women with gestational diabetes mellitus, maternal FPG concentrations during pregnancy were significantly and positively associated with offspring birth size and overweight/obesity risk at 7 y, adjusting for maternal prepregnancy BMI.
Details
- Title: Subtitle
- Growth and obesity through the first 7 y of life in association with levels of maternal glycemia during pregnancy: a prospective cohort study
- Creators
- Yeyi Zhu - From the Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Rockville, MDSjurdur F Olsen - Centre for Fetal Programming, Department of Epidemiology Research, Statens Serum Institut, Copenhagen, DenmarkPauline Mendola - From the Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Rockville, MDEdwina H Yeung - From the Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Rockville, MDAllan Vaag - Department of Endocrinology andKatherine Bowers - From the Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Rockville, MDAiyi Liu - From the Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Rockville, MDWei Bao - From the Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Rockville, MDShanshan Li - From the Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Rockville, MDCamilla Madsen - Department of Endocrinology andLouise G Grunnet - Department of Endocrinology andCharlotta Granström - Centre for Fetal Programming, Department of Epidemiology Research, Statens Serum Institut, Copenhagen, DenmarkSusanne Hansen - Centre for Fetal Programming, Department of Epidemiology Research, Statens Serum Institut, Copenhagen, DenmarkKelly Martin - From the Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Rockville, MDJorge E Chavarro - Departments of Nutrition and Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA; andFrank B Hu - Departments of Nutrition and Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA; andJens Langhoff-Roos - Department of Obstetrics, Rigshospitalet University Hospital, Copenhagen, DenmarkPeter Damm - Center for Pregnant Women With Diabetes, Department of Obstetrics, Rigshospitalet, The Institute of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, DenmarkCuilin Zhang - From the Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Rockville, MD; zhangcu@mail.nih.gov
- Resource Type
- Journal article
- Publication Details
- The American journal of clinical nutrition, Vol.103(3), pp.794-800
- Publisher
- United States
- DOI
- 10.3945/ajcn.115.121780
- PMID
- 26817507
- PMCID
- PMC4763496
- ISSN
- 1938-3207
- eISSN
- 1938-3207
- Grant note
- Intramural NIH HHS
- Language
- English
- Date published
- 03/2016
- Academic Unit
- Epidemiology; Fraternal Order of Eagles Diabetes Research Center
- Record Identifier
- 9983995003302771
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