Journal article
Growth in VLBW infants fed predominantly fortified maternal and donor human milk diets: a retrospective cohort study
BMC pediatrics, Vol.12(1), pp.124-124
08/17/2012
DOI: 10.1186/1471-2431-12-124
PMCID: PMC3464178
PMID: 22900590
Abstract
Background
To determine the effect of human milk, maternal and donor, on in-hospital growth of very low birthweight (VLBW) infants. We performed a retrospective cohort study comparing in-hospital growth in VLBW infants by proportion of human milk diet, including subgroup analysis by maternal or donor milk type. Primary outcome was change in weight z-score from birth to hospital discharge.
Methods
Retrospective cohort study.
Results
171 infants with median gestational age 27 weeks (IQR 25.4, 28.9) and median birthweight 899 g (IQR 724, 1064) were included. 97% of infants received human milk, 51% received > 75% of all enteral intake as human milk. 16% of infants were small-for-gestational age (SGA, < 10th percentile) at birth, and 34% of infants were SGA at discharge. Infants fed >75% human milk had a greater negative change in weight z-score from birth to discharge compared to infants receiving < 75% (−0.6 vs, -0.4, p = 0.03). Protein and caloric supplementation beyond standard human milk fortifier was related to human milk intake (p = 0.04). Among infants receiving > 75% human milk, there was no significant difference in change in weight z-score by milk type (donor −0.84, maternal −0.56, mixed −0.45, p = 0.54). Infants receiving >75% donor milk had higher rates of SGA status at discharge than those fed maternal or mixed milk (56% vs. 35% (maternal), 21% (mixed), p = 0.08).
Conclusions
VLBW infants can grow appropriately when fed predominantly fortified human milk. However, VLBW infants fed >75% human milk are at greater risk of poor growth than those fed less human milk. This risk may be highest in those fed predominantly donor human milk.
Details
- Title: Subtitle
- Growth in VLBW infants fed predominantly fortified maternal and donor human milk diets: a retrospective cohort study
- Creators
- Tarah T Colaizy - Department of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, USASusan Carlson - Department of Food and Nutrition, University of Iowa Hospitals and Clinics, Iowa City, USAAudrey F Saftlas - Department of Epidemiology College of Public Health, University of Iowa, Iowa City, USAFrank H Morriss Jr - Department of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, USA
- Resource Type
- Journal article
- Publication Details
- BMC pediatrics, Vol.12(1), pp.124-124
- DOI
- 10.1186/1471-2431-12-124
- PMID
- 22900590
- PMCID
- PMC3464178
- NLM abbreviation
- BMC Pediatr
- ISSN
- 1471-2431
- eISSN
- 1471-2431
- Publisher
- BioMed Central
- Language
- English
- Date published
- 08/17/2012
- Academic Unit
- Stead Family Department of Pediatrics; Epidemiology; Neonatology
- Record Identifier
- 9984093346102771
Metrics
11 Record Views