Journal article
Guanosine 5'-O-(3-thiotrisphosphate) potentiates both thrombin- and platelet-derived growth factor-induced inositol phosphate release in permeabilized vascular smooth muscle cells. Signaling mechanisms distinguished by sensitivity to pertussis toxin and phorbol esters
The Journal of biological chemistry, Vol.264(8), pp.4391-4397
01/01/1989
DOI: 10.1016/S0021-9258(18)83754-1
PMID: 2494171
Abstract
The authors compared the mechanisms by which thrombin and platelet-derived growth factor (PDGF) activate phospholipase C in cultured vascular smooth muscle cells. Thrombin caused a transient (< 5 min) increase in inositol trisphosphate (IP sub(3)) while PDGF caused a sustained (> 10 min) increase. Thrombin and PDGF activate phospholipase C by signal transduction systems which differ in kinetic properties and in sensitivity to PMA and pertussis toxin. Despite these differences, both systems appear to involve GTP binding proteins at some step.
Details
- Title: Subtitle
- Guanosine 5'-O-(3-thiotrisphosphate) potentiates both thrombin- and platelet-derived growth factor-induced inositol phosphate release in permeabilized vascular smooth muscle cells. Signaling mechanisms distinguished by sensitivity to pertussis toxin and phorbol esters
- Creators
- Chou-Long HuangHarlan E Ives
- Resource Type
- Journal article
- Publication Details
- The Journal of biological chemistry, Vol.264(8), pp.4391-4397
- DOI
- 10.1016/S0021-9258(18)83754-1
- PMID
- 2494171
- NLM abbreviation
- J Biol Chem
- ISSN
- 0021-9258
- eISSN
- 1083-351X
- Language
- English
- Date published
- 01/01/1989
- Academic Unit
- Nephrology; Internal Medicine
- Record Identifier
- 9984359929902771
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