Journal article
Guarding Pain and Spontaneous Activity of Nociceptors after Skin versus Skin Plus Deep Tissue Incision
Anesthesiology (Philadelphia), Vol.112(1), pp.153-164
01/01/2010
DOI: 10.1097/ALN.0b013e3181c2952e
PMCID: PMC2907154
PMID: 19996955
Abstract
Background: Guarding pain after rat plantar incision is similar to pain at rest in postoperative patients. Spontaneous activity (SA) in nociceptive pathways quite likely transmits Such ongoing pain. This study examined the extent of tissue injury by incision on pain behaviors and nociceptor SA.
Methods: Rat pain behaviors were measured after a sham procedure, skin incision, or skin plus deep tissue incision. Separate groups of rats underwent in vivo single-fiber recording 1 day after a sham procedure, skin, or skin plus deep tissue incision or 7 days after skin plus deep tissue incision.
Results: Compared with the control procedure, skin incision induced moderate guarding on the day of incision only, whereas skin plus deep tissue incision caused guarding for 5 days. Mechanical and heat hyperalgesia were similar in both incised groups, except that mechanical hyperalgesia lasted longer after skin plus deep tissue incision. On Postoperative Day 1, skin incision (18.2%) produced a similar prevalence of SA in nociceptors as in controls (13.0%), whereas skin plus deep tissue incision generated a greater prevalence of SA (61.0%); SA rate also tended to be greater (6.1 vs. 10.0 imp/s) after skin plus deep tissue incision. Seven days after skin plus deep tissue incision, the SA prevalence was similar (13.6%) as it) controls.
Conclusions: These data demonstrated that incised deep tissue rather than skin had a central role in the genesis of guarding behavior and nociceptor SA. Understanding the responses of deep tissue to incision and the mechanisms for deep tissue pain will improve postoperative pain management
Details
- Title: Subtitle
- Guarding Pain and Spontaneous Activity of Nociceptors after Skin versus Skin Plus Deep Tissue Incision
- Creators
- Jun Xu - University of IowaTimothy J. Brennan - University of Iowa Hospitals and Clinics
- Resource Type
- Journal article
- Publication Details
- Anesthesiology (Philadelphia), Vol.112(1), pp.153-164
- Publisher
- Lippincott Williams & Wilkins
- DOI
- 10.1097/ALN.0b013e3181c2952e
- PMID
- 19996955
- PMCID
- PMC2907154
- ISSN
- 0003-3022
- eISSN
- 1528-1175
- Number of pages
- 12
- Grant note
- Department of Anesthesia at the University of Iowa GM-55831 / National Institutes of Health, Bethesada, Maryland; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA R01GM055831 / NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of General Medical Sciences (NIGMS)
- Language
- English
- Date published
- 01/01/2010
- Academic Unit
- Surgery; Anesthesia
- Record Identifier
- 9984322959502771
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