Journal article
Guidelines for Management of Hyperlipidemia: Implications for Treatment of Patients with Stroke Secondary to Atherosclerotic Disease
Current Neurology and Neuroscience Reports, Vol.16(3), pp.1-9
03/2016
DOI: 10.1007/s11910-016-0621-1
PMID: 26838351
Abstract
After careful review of randomized cardiovascular outcomes trial data, the 2013 ACC/AHA cholesterol guideline focused on using the appropriate intensity of statin therapy to reduce atherosclerotic cardiovascular disease (ASCVD) risk and moved away from recommending specific low-density lipoprotein cholesterol (LDL-C) treatment targets. In patients who have had a stroke or other clinical ASCVD event, a high-intensity statin should be initiated up to age 75 years unless there are safety concerns, including a history of hemorrhagic stroke. A moderate-intensity statin is recommended if there are safety concerns or age is greater than 75 years. Atorvastatin 40–80 mg and rosuvastatin 20–40 mg are considered high-intensity statins. These new guidelines avoid unnecessary usage of non-statins to achieve specific LDL-C values, thus avoiding potential adverse effects or use of an inadequate statin intensity in patients who are “at goal.” When non-statins are considered for additional LDL-C lowering, ezetimibe is the only non-statin clearly shown to further reduce ASCVD risk when added to background statin therapy.
Details
- Title: Subtitle
- Guidelines for Management of Hyperlipidemia: Implications for Treatment of Patients with Stroke Secondary to Atherosclerotic Disease
- Creators
- Sudeepta Dandapat - Department of Neurology University of Iowa Iowa City IA USAJennifer Robinson - Departments of Epidemiology & Medicine, Prevention Intervention Center College of Public Health, University of Iowa 145 N Riverside Drive S455 CPHB Iowa City IA 52242-2007 USA
- Resource Type
- Journal article
- Publication Details
- Current Neurology and Neuroscience Reports, Vol.16(3), pp.1-9
- Publisher
- Springer US; New York
- DOI
- 10.1007/s11910-016-0621-1
- PMID
- 26838351
- ISSN
- 1528-4042
- eISSN
- 1534-6293
- Language
- English
- Date published
- 03/2016
- Academic Unit
- Neurology; Epidemiology; Fraternal Order of Eagles Diabetes Research Center; Internal Medicine
- Record Identifier
- 9983996198502771
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