Journal article
Gut-Brain Axis and its Neuro-Psychiatric Effects: A Narrative Review
Curēus (Palo Alto, CA), Vol.12(10), p.e11131
10/24/2020
DOI: 10.7759/cureus.11131
PMID: 33240722
Abstract
The gut microbiota regulates the function and health of the human gut. Preliminary evidence suggests its impact on multiple human systems including the nervous and immune systems. A major area of research has been the directional relationship between intestinal microbiota and the central nervous system (CNS), called the microbiota-gut-brain axis. It is hypothesized that the intestinal microbiota affects brain activity and behavior via endocrine, neural, and immune pathways. An alteration in the composition of the gut microbiome has been linked to a variety of neurodevelopmental and neurodegenerative disorders. The connection between gut microbiome and several CNS disorders indicates that the focus of research in the future should be on the bacterial and biochemical targets. Through this review, we outline the established knowledge regarding the gut microbiome and gut-brain axis. In addition to gut microbiome in neurological and psychiatry diseases, we have briefly discussed microbial metabolites affecting the blood-brain barrier (BBB), immune dysregulation, modification of autonomic sensorimotor connections, and hypothalamus-pituitary-adrenal axis.
Details
- Title: Subtitle
- Gut-Brain Axis and its Neuro-Psychiatric Effects: A Narrative Review
- Creators
- Likhita Shaik - Mayo ClinicRahul Kashyap - Mayo ClinicSahith Reddy Thotamgari - Louisiana State University Health Sciences Center ShreveportRomil SinghSahil Khanna - Mayo Clinic
- Resource Type
- Journal article
- Publication Details
- Curēus (Palo Alto, CA), Vol.12(10), p.e11131
- DOI
- 10.7759/cureus.11131
- PMID
- 33240722
- NLM abbreviation
- Cureus
- ISSN
- 2168-8184
- eISSN
- 2168-8184
- Publisher
- Cureus
- Language
- English
- Date published
- 10/24/2020
- Academic Unit
- Neurology
- Record Identifier
- 9985143549202771
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