Journal article
Gut Microbiota Regulates the Sympathetic Nerve Activity and Peripheral Serotonin Through Hypothalamic MicroRNA-204 in Order to Increase the Browning of White Adipose Tissue in Obesity
Curēus (Palo Alto, CA), Vol.14(2), pp.e21913-e21913
02/04/2022
DOI: 10.7759/cureus.21913
PMCID: PMC8820388
PMID: 35155042
Abstract
The prevalence of obesity is increasing worldwide, and novel therapeutic strategies such as enhancement of thermogenic pathways in white adipose tissue (WAT) are gaining more attention. The gut/brain axis plays an essential role in promoting the browning of WAT. However, the mechanism by which this axis regulates WAT function is not fully understood. On the other hand, the role of microRNAs (miRNAs) in the control of WAT browning has already been established. Therefore, understanding the communication pathways linking the gut/brain axis and miRNAs might establish a promising intervention for obesity.
Our published data showed that microRNA-204 (miR-204), a microRNA that plays an important role in the control of the central nervous system (CNS) and the pathogenesis of obesity, is affected by gut dysbiosis. Therefore, miR-204 could be a key element that controls the browning of WAT by acting as a potential link between the gut microbiota and the brain. In this review, we summarized the current knowledge about communication pathways between the brain, gut, and miR-204 and examined the literature to discuss potential research directions that might lead to a better understanding of the mechanisms underlying the browning of WAT in obesity.
Details
- Title: Subtitle
- Gut Microbiota Regulates the Sympathetic Nerve Activity and Peripheral Serotonin Through Hypothalamic MicroRNA-204 in Order to Increase the Browning of White Adipose Tissue in Obesity
- Creators
- Adam Kassan - West Coast UniversityKarima Ait-Aissa - University of IowaModar Kassan - University of Tennessee at Knoxville
- Resource Type
- Journal article
- Publication Details
- Curēus (Palo Alto, CA), Vol.14(2), pp.e21913-e21913
- DOI
- 10.7759/cureus.21913
- PMID
- 35155042
- PMCID
- PMC8820388
- NLM abbreviation
- Cureus
- ISSN
- 2168-8184
- eISSN
- 2168-8184
- Publisher
- Cureus Inc
- Number of pages
- 5
- Language
- English
- Date published
- 02/04/2022
- Academic Unit
- Cardiovascular Medicine; Internal Medicine
- Record Identifier
- 9984361563502771
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