Journal article
Gut microbiota short-chain fatty acids and their impact on the host thyroid function and diseases
Frontiers in endocrinology (Lausanne), Vol.14, 1192216
06/30/2023
DOI: 10.3389/fendo.2023.1192216
PMCID: PMC10349397
PMID: 37455925
Abstract
Thyroid disorders are clinically characterized by alterations of L-3,5,3’,5’-tetraiodothyronine (T 4 ), L-3,5,3’-triiodothyronine (T 3 ), and/or thyroid-stimulating hormone (TSH) levels in the blood. The most frequent thyroid disorders are hypothyroidism, hyperthyroidism, and hypothyroxinemia. These conditions affect cell differentiation, function, and metabolism. It has been reported that 40% of the world’s population suffers from some type of thyroid disorder and that several factors increase susceptibility to these diseases. Among them are iodine intake, environmental contamination, smoking, certain drugs, and genetic factors. Recently, the intestinal microbiota, composed of more than trillions of microbes, has emerged as a critical player in human health, and dysbiosis has been linked to thyroid diseases. The intestinal microbiota can affect host physiology by producing metabolites derived from dietary fiber, such as short-chain fatty acids (SCFAs). SCFAs have local actions in the intestine and can affect the central nervous system and immune system. Modulation of SCFAs-producing bacteria has also been connected to metabolic diseases, such as obesity and diabetes. In this review, we discuss how alterations in the production of SCFAs due to dysbiosis in patients could be related to thyroid disorders. The studies reviewed here may be of significant interest to endocrinology researchers and medical practitioners.
Details
- Title: Subtitle
- Gut microbiota short-chain fatty acids and their impact on the host thyroid function and diseases
- Creators
- María José Mendoza-León - Millennium Institute on Immunology and ImmunotherapyAshutosh K. Mangalam - University of IowaAlejandro Regaldiz - Millennium Institute on Immunology and ImmunotherapyEnrique González-Madrid - Millennium Institute on Immunology and ImmunotherapyMa. Andreina Rangel-Ramírez - Millennium Institute on Immunology and ImmunotherapyOscar Álvarez-Mardonez - Millennium Institute on Immunology and ImmunotherapyOmar P. Vallejos - Millennium Institute on Immunology and ImmunotherapyConstanza Méndez - Millennium Institute on Immunology and ImmunotherapySusan M. Bueno - Millennium Institute on Immunology and ImmunotherapyFelipe Melo-González - Millennium Institute on Immunology and ImmunotherapyYorley Duarte - Universidad Andrés BelloMa. Cecilia Opazo - Millennium Institute on Immunology and ImmunotherapyAlexis M. Kalergis - Millennium Institute on Immunology and ImmunotherapyClaudia A. Riedel - Millennium Institute on Immunology and Immunotherapy
- Resource Type
- Journal article
- Publication Details
- Frontiers in endocrinology (Lausanne), Vol.14, 1192216
- DOI
- 10.3389/fendo.2023.1192216
- PMID
- 37455925
- PMCID
- PMC10349397
- NLM abbreviation
- Front Endocrinol (Lausanne)
- ISSN
- 1664-2392
- eISSN
- 1664-2392
- Grant note
- DOI: 10.13039/501100013928, name: Instituto Milenio en Inmunología e Inmunoterapia; DOI: 10.13039/501100020884, name: Agencia Nacional de Investigación y Desarrollo, award: 21211419, 21202085; DOI: 10.13039/501100002850, name: Fondo Nacional de Desarrollo Científico y Tecnológico, award: 1191300, 11200764, 11201113
- Language
- English
- Date published
- 06/30/2023
- Academic Unit
- Pathology; Iowa Neuroscience Institute
- Record Identifier
- 9984442226502771
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