Journal article
H-2 control of expression of an idiotype shared by normal B cells and a B-cell lymphoma
Immunogenetics (New York), Vol.21(4), pp.355-366
1985
DOI: 10.1007/BF00430801
PMID: 3922882
Abstract
The spleens of normal B10.H-2aH-4bp/Wts (2a4b) mice contain cells which, in response to mitogen stimulation, secrete hemolytic antibody specific for a determinant present on both sheep and bromelain-treated mouse erythrocytes. These cells were found to be Ly-1 positive. Approximately 50% of these cells bear surface immunoglobulin (sIg) with the same idiotype as the sIg of a 2a4b-derived B-cell lymphoma, CH12. Backcross analysis revealed H-2 control of the frequency of the idiotype-positive B cell. The regulatory gene did not correlate with the Igh-1 allotype, and analysis of 22 inbred mouse strains mapped the gene to the I-E subregion. Surprisingly, only strains homozygous for Ek alpha expressed the idiotype, and expression was a recessive trait. Possible mechanisms for this control of idiotype expression and its relation to lymphomagenesis are discussed.
Details
- Title: Subtitle
- H-2 control of expression of an idiotype shared by normal B cells and a B-cell lymphoma
- Creators
- Gail Abendroth BishopGeoffrey Haughton
- Resource Type
- Journal article
- Publication Details
- Immunogenetics (New York), Vol.21(4), pp.355-366
- DOI
- 10.1007/BF00430801
- PMID
- 3922882
- ISSN
- 0093-7711
- eISSN
- 1432-1211
- Language
- English
- Date published
- 1985
- Academic Unit
- Microbiology and Immunology; President
- Record Identifier
- 9984001122002771
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