Journal article
H1N1 2009 influenza virus infection during pregnancy in the USA
The Lancet (British edition), Vol.374(9688), pp.451-458
08/08/2009
DOI: 10.1016/S0140-6736(09)61304-0
PMID: 19643469
Abstract
Background Pandemic HlN1 2009 influenza virus has been identified as the cause of a widespread outbreak of febrile respiratory infection in the USA and worldwide. We summarised cases of infection with pandemic H1N1 virus in pregnant women identified in the USA during the first month of the present outbreak, and deaths associated with this virus during the first 2 months of the outbreak.
Methods After initial reports of infection in pregnant women, the US Centers for Disease Control and Prevention (CDC) began systematically collecting additional information about cases and deaths in pregnant women in the USA with pandemic H1N1 virus infection as part of enhanced surveillance. A confirmed case was defined as an acute respiratory illness with laboratory-confirmed pandemic H1N1 virus infection by real-time reverse-transcriptase PCR or viral culture; a probable case was defined as a person with an acute febrile respiratory illness who was positive for influenza A, but negative for H1 and H3. We used population estimates derived from the 2007 census data to calculate rates of admission to hospital and illness.
Findings From April 15 to May 18, 2009, 34 confirmed or probable cases of pandemic H1N1 in pregnant women were reported to CDC from 13 states. 11 (32%) women were admitted to hospital. The estimated rate of admission for pandemic H1N1 influenza virus infection in pregnant women during the first month of the outbreak was higher than it was in the general population (0.32 per 100000 pregnant women, 95% CI 0.13-0.52 vs 0.076 per 100 000 population at risk, 95% CI 0.07-0.09). Between April 15 and June 16, 2009, six deaths in pregnant women were reported to the CDC; all were in women who had developed pneumonia and subsequent acute respiratory distress syndrome requiring mechanical ventilation.
Interpretation Pregnant women might be at increased risk for complications from pandemic H1N1 virus infection. These data lend support to the present recommendation to promptly treat pregnant women with H1N1 influenza virus infection with anti-influenza drugs.
Funding US CDC.
Details
- Title: Subtitle
- H1N1 2009 influenza virus infection during pregnancy in the USA
- Creators
- Denise J. Jamieson - National Center for Chronic Disease Prevention and Health PromotionMargaret A. Honein - Centers for Disease Control and PreventionSonja A. Rasmussen - National Center on Birth Defects and Developmental DisabilitiesJennifer L. Williams - National Center on Birth Defects and Developmental DisabilitiesDavid L. Swerdlow - National Center for Immunization and Respiratory DiseasesMatthew S. Biggerstaff - National Center for Immunization and Respiratory DiseasesStephen Lindstrom - National Center for Immunization and Respiratory DiseasesJanice K. Louie - California Department of Public HealthCara M. Christ - Arizona Department of Health ServicesSusan R. Bohm - Michigan Department of Health and Human ServicesVincent P. Fonseca - Texas Department of State Health ServicesKathleen A. Ritger - Chicago Department of Public HealthDanel J. Kuhles - Nassau Cty Dept Hlth, Uniondale, NY USAPaula Eggers - Delaware Division of Public HealthHollianne Bruce - Snohomish Health DistrictHeidi A. Davidson - DeKalb County Board of HealthEmily Lutterloh - Centers for Disease Control and PreventionMeghan L. Harris - Iowa Department of Public HealthColleen Burke - Philadelphia Department of Public HealthNoelle Cocoros - Massachusetts Department of Public HealthLyn Finelli - Centers for Disease Control and PreventionKitty F. MacFarlane - National Center for Chronic Disease Prevention and Health PromotionBo Shu - National Center for Immunization and Respiratory DiseasesSonja J. Olsen - National Center for Immunization and Respiratory DiseasesNovel Influenza A (H1N1) Pregnancy Working Group
- Resource Type
- Journal article
- Publication Details
- The Lancet (British edition), Vol.374(9688), pp.451-458
- Publisher
- Elsevier
- DOI
- 10.1016/S0140-6736(09)61304-0
- PMID
- 19643469
- ISSN
- 0140-6736
- eISSN
- 1474-547X
- Number of pages
- 8
- Grant note
- US CDC; United States Department of Health & Human Services; Centers for Disease Control & Prevention - USA
- Language
- English
- Date published
- 08/08/2009
- Academic Unit
- Obstetrics and Gynecology; VPMA - Administration
- Record Identifier
- 9984446444302771
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