Journal article
HAND1 and HAND2 are expressed in the adult-rodent heart and are modulated during cardiac hypertrophy
Biochemical and biophysical research communications, Vol.297(4), pp.870-875
2002
DOI: 10.1016/S0006-291X(02)02297-0
PMID: 12359233
Abstract
The HAND basic Helix-Loop-Helix (bHLH) transcription factors are essential for normal cardiac and extraembryonic development. Although highly evolutionarily conserved genes,
HAND cardiac expression patterns differ across species. Mouse expression of
HAND1 and
HAND2 was reported absent in the adult heart. Human
HAND genes are expressed in the adult heart and
HAND1 expression is downregulated in cardiomyopathies. As rodent and human expression profiles are inconsistent, we re-examined expression of
HAND1 and
HAND2 in adult-rodent hearts.
HAND1 and
HAND2 are expressed in adult-rodent hearts and
HAND2 is expressed in the atria. Induction of cardiac hypertrophy shows modulation of
HAND expression, corresponding with observations in human cardiomyopathy. The downregulation of
HAND expression observed in rodent hypertrophy and human cardiomyopathy may reflect a permissive role allowing, cardiomyocytes to reinitiate the fetal gene program and initiate the adaptive physiological changes that allow the heart to compensate (hypertrophy) for the increase in afterload.
Details
- Title: Subtitle
- HAND1 and HAND2 are expressed in the adult-rodent heart and are modulated during cardiac hypertrophy
- Creators
- Bijoy D Thattaliyath - Department of Physiology, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, Mail code-7756, San Antonio, TX 78229-3900, USACarolina B Livi - Department of Physiology, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, Mail code-7756, San Antonio, TX 78229-3900, USAMark E Steinhelper - Department of Physiology, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, Mail code-7756, San Antonio, TX 78229-3900, USAGlenn M Toney - Department of Physiology, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, Mail code-7756, San Antonio, TX 78229-3900, USAAnthony B Firulli - Department of Physiology, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, Mail code-7756, San Antonio, TX 78229-3900, USA
- Resource Type
- Journal article
- Publication Details
- Biochemical and biophysical research communications, Vol.297(4), pp.870-875
- Publisher
- Elsevier Inc
- DOI
- 10.1016/S0006-291X(02)02297-0
- PMID
- 12359233
- ISSN
- 0006-291X
- eISSN
- 1090-2104
- Language
- English
- Date published
- 2002
- Academic Unit
- Cardiology; Stead Family Department of Pediatrics
- Record Identifier
- 9984093313302771
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