Journal article
HDAC4 Regulates Muscle Fiber Type-Specific Gene Expression Programs
Molecules and cells, Vol.38(4), pp.343-348
02/25/2015
DOI: 10.14348/molcells.2015.2278
PMCID: PMC4400309
PMID: 25728750
Abstract
Fiber type-specific programs controlled by the transcription factor MEF2 dictate muscle functionality. Here, we show that HDAC4, a potent MEF2 inhibitor, is predominantly localized to the nuclei in fast/glycolytic fibers in contrast to the sarcoplasm in slow/oxidative fibers. The cytoplasmic localization is associated with HDAC4 hyper-phosphorylation in slow/oxidative-fibers. Genetic reprogramming of fast/glycolytic fibers to oxidative fibers by active CaMKII or calcineurin leads to increased HDAC4 phosphorylation, HDAC4 nuclear export, and an increase in markers associated with oxidative fibers. Indeed, HDAC4 represses the MEF2-dependent, PGC-1α-mediated oxidative metabolic gene program. Thus differential phosphorylation and localization of HDAC4 contributes to establishing fiber type-specific transcriptional programs.
Details
- Title: Subtitle
- HDAC4 Regulates Muscle Fiber Type-Specific Gene Expression Programs
- Creators
- Todd J Cohen - Duke UniversityMoon-Chang Choi - Duke UniversityMeghan Kapur - Duke UniversityVitor A Lira - University of VirginiaZhen Yan - University of VirginiaTso-Pang Yao - Duke University
- Resource Type
- Journal article
- Publication Details
- Molecules and cells, Vol.38(4), pp.343-348
- Publisher
- Korean Society for Molecular and Cellular Biology
- DOI
- 10.14348/molcells.2015.2278
- PMID
- 25728750
- PMCID
- PMC4400309
- ISSN
- 1016-8478
- eISSN
- 0219-1032
- Language
- English
- Date published
- 02/25/2015
- Academic Unit
- Health and Human Physiology
- Record Identifier
- 9984259391202771
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