Journal article
HEMODYNAMIC AND METABOLIC RESPONSE AFTER ABRUPT WITHDRAWAL OF LONG-TERM PROPRANOLOL
Circulation (New York, N.Y.), Vol.58(2), pp.196-201
01/01/1978
DOI: 10.1161/01.CIR.58.2.196
PMID: 566642
Abstract
The effect of cessation of propranolol on .beta. receptor reactivity to catecholamine stimulation was studied. Heart rate and maximum rate of rise of left ventricular pressure (dP/dt max [maximum change in pressure with time]) during isoproterenol infusions and plasma free fatty acids (FFA) after epinephrine infusions were measured in 6 conscious dogs before, during and after 4 wk of oral propranolol (40 mg orally every 8 h). Rises in heart rate, dP/dt max and FFA were blocked during propranolol administration. Twenty-four hours after withdrawal from propranolol, heart rate and dP/dt max responses remained significantly attenuated, although FFA responses were at premedication levels. The 72-h, 96-h and 1 wk postmedication responses did not differ from premedication values. Partial .beta. blockade of the heart was still present at 24 h and no evidence of heightened .beta. receptor sensitivity was detected on repeated study 1 wk after withdrawal from a long-term, high dose propranolol regimen.
Details
- Title: Subtitle
- HEMODYNAMIC AND METABOLIC RESPONSE AFTER ABRUPT WITHDRAWAL OF LONG-TERM PROPRANOLOL
- Creators
- J H Myers - Bristol-Myers SquibbL D Horwitz
- Resource Type
- Journal article
- Publication Details
- Circulation (New York, N.Y.), Vol.58(2), pp.196-201
- Publisher
- Lippincott Williams & Wilkins
- DOI
- 10.1161/01.CIR.58.2.196
- PMID
- 566642
- ISSN
- 0009-7322
- eISSN
- 1524-4539
- Number of pages
- 6
- Language
- English
- Date published
- 01/01/1978
- Academic Unit
- Cardiovascular Medicine; Internal Medicine
- Record Identifier
- 9984656528402771
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