Journal article
HIV Mono-infection Is Associated With FIB-4 – A Noninvasive Index of Liver Fibrosis – in Women
Clinical infectious diseases, Vol.52(5), pp.674-680
03/01/2011
DOI: 10.1093/cid/ciq199
PMCID: PMC3106241
PMID: 21248367
Abstract
Predictors of liver fibrosis were evaluated in women using a noninvasive index (FIB-4). HIV RNA levels were associated with increased FIB-4 in the absence of viral hepatitis, alcohol use, or antiretroviral therapy. These data complement evidence suggesting a potential relationship between HIV infection and hepatic fibrosis.
Background.
FIB-4 represents a noninvasive, composite index that is a validated measure of hepatic fibrosis, which is an important indicator of liver disease. To date, there are limited data regarding hepatic fibrosis in women.
Methods.
FIB-4 was evaluated in a cohort of 1227 women, and associations were evaluated in univariate and multivariate regression models among 4 groups of subjects classified by their human immunodeficiency virus (HIV) and hepatitis C virus (HCV) infection status.
Results.
The median FIB-4 scores were 0.60 in HIV-/HCV- women, 0.83 in HIV-/HCV+ women, 0.86 in HIV+/HCV- women, and 1.30 in HIV+/HCV+ women. In the HIV/HCV co-infected group, multivariate analysis showed that CD4
+
cell count and albumin level were negatively associated with FIB-4 (
P
<.0001), whereas antiretroviral therapy (ART) was positively associated with FIB-4 score (
P
=.0008). For the HIV mono-infected group, multivariate analysis showed that CD4
+
cell count (
P
<.0001) and albumin level (
P
=.0019) were negatively correlated with FIB-4 score, ART was positively associated with FIB-4 score (
P
=.0008), and plasma HIV RNA level was marginally associated with FIB-4 score (
P
=.080). In 72 HIV mono-infected women who were also hepatitis B surface antigen negative, ART naive, and reported no recent alcohol intake, plasma HIV RNA level was associated with increased FIB-4 score (
P
=.030).
Conclusions.
HIV RNA level was associated with increased FIB-4 score in the absence of hepatitis B, hepatitis C, ART, or alcohol use, suggesting a potential relationship between HIV infection and hepatic fibrosis in vivo. A better understanding of the various demographic and virologic variables that contribute to hepatic fibrosis may lead to more effective treatment of HIV infection and its co-morbid conditions.
Details
- Title: Subtitle
- HIV Mono-infection Is Associated With FIB-4 – A Noninvasive Index of Liver Fibrosis – in Women
- Creators
- Jason T. Blackard - Johns Hopkins UniversityJeffrey A. Welge - University of Cincinnati Medical CenterLynn E. Taylor - Miriam HospitalKenneth H. Mayer - Miriam HospitalRobert S. Klein - Icahn School of Medicine at Mount SinaiDavid D. Celentano - Johns Hopkins UniversityDenise J. Jamieson - Johns Hopkins UniversityLytt Gardner - Centers for Disease Control and PreventionKenneth E. Sherman - Johns Hopkins University
- Resource Type
- Journal article
- Publication Details
- Clinical infectious diseases, Vol.52(5), pp.674-680
- Publisher
- Oxford University Press
- DOI
- 10.1093/cid/ciq199
- PMID
- 21248367
- PMCID
- PMC3106241
- ISSN
- 1058-4838
- eISSN
- 1537-6591
- Language
- English
- Date published
- 03/01/2011
- Academic Unit
- Obstetrics and Gynecology; VPMA - Administration
- Record Identifier
- 9984446282402771
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